CD8 cytotoxic T cells in cutaneous leishmaniasis

被引:60
|
作者
Ruiz, J. H. [1 ]
Becker, I. [1 ]
机构
[1] Univ Nacl Autonoma Mexico, Fac Med, Dept Expt Med, Mexico City 06726, DF, Mexico
关键词
CD8 T cell; cytotoxicity; Leishmana;
D O I
10.1111/j.1365-3024.2007.00991.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
CD8 T cells are essential in the defence against viruses, yet little is known of their participation in the host defence against parasites, such as Leishmania, which can cause a variety of clinical diseases, such as localized cutaneous, diffuse cutaneous, mucocutaneous and visceral leishmaniasis. Murine models of leishmaniasis suggest that CD8 T cells participate through IFN-gamma production, yet their cytotoxic capacity also plays an important role, as has been found in patients infected with various Leishmania strains, where CD8 T cell cytotoxicity and apoptosis of autologous Leishmania-infected macrophages correlate with cure. Yet the mechanisms underlying the CD8 T activation in patients with leishmaniasis remain an enigma. It is possible that dendritic cells activate CD8 T cells through mechanisms that include antigen cross-presentation. Here we summarize the recent findings of CD8 T cells in cutaneous leishmaniasis and discuss their significance in the control of the disease. Further knowledge in this field will undoubtedly improve the design of therapeutic and vaccine strategies.
引用
收藏
页码:671 / 678
页数:8
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