Ascorbic acid antagonizes the inhibitory effect of acute ethanol on nitrite levels in the striatum of freely moving mice

被引：2

作者：

Yan, PG ^{[1
]}

Wu, CF ^{[1
]}

Huang, M ^{[1
]}

Liu, W ^{[1
]}

Yang, JY ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang 110016, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2003年 / 352卷 / 03期

关键词：

ethanol; ascorbic acid; nitrites; striatum;

D O I：

10.1016/j.neulet.2003.08.063

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of exogenous ascorbic acid (AA) on acute ethanol-induced decrease in extracellular nitrites contents in striatum of freely moving mice was investigated by using microdialysis coupled to high performance liquid chromatography with electrochemical detection. The results showed that exogenous AA had no effect on basal extracellular levels of nitrites, but significantly increased striatal extracellular contents of AA in a dose-depended manner. Co-administration of AA with ethanol significantly antagonized the ethanol-induced decrease in extracellular nitrites contents, but did not affect ethanol-induced release of AA. These data provided the first evidence of an antagonistic action of AA on ethanol-induced decrease in extracellular nitrites contents in striatum of freely moving mice. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：183 / 186

页数：4

共 45 条

[41] EFFECT OF 1,5-DICAFFEYLQUINIC ACID (CYNARINE) ON CHOLESTEROL LEVELS IN SERUM AND LIVER OF ACUTE ETHANOL-TREATED RATS
WOJCICKI, J
[J]. DRUG AND ALCOHOL DEPENDENCE, 1978, 3 (02) : 143 - 145
[42] STUDIES IN ASCORBIC ACID WITH ESPECIAL REFERENCE TO THE WHITE LAYER .2. THE RELATION OF INTAKE TO BLOOD LEVELS IN NORMAL CHILDREN AND THE EFFECT OF ACUTE AND CHRONIC ILLNESS
WILSON, MG
LUBSCHEZ, R
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1946, 25 (03): : 428 - 436
[43] Acute exposure to perfluorononanoic acid in prepubertal mice: Effect on germ cell dynamics and an insight into the possible mechanisms of its inhibitory action on testicular functions
Singh, Shilpi
Singh, Shio Kumar
[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 183
[44] EFFECT OF ANTIOXIDANT-RICH FOODS ON PLASMA ASCORBIC-ACID, CARDIAC ENZYME, AND LIPID PEROXIDE LEVELS IN PATIENTS HOSPITALIZED WITH ACUTE MYOCARDIAL-INFARCTION
SINGH, RB
NIAZ, MA
AGARWAL, P
BEGOM, R
RASTOGI, SS
[J]. JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION, 1995, 95 (07) : 775 - 780
[45] Differential effect of β-N-oxalylamino-L-alanine, the Lathyrus sativus neurotoxin, and (±)-α-amino-3-hydroxy-5-methylisoxazole-4-propionate on the excitatory amino acid and taurine levels in the brain of freely moving rats
La Bella, V
Piccoli, F
[J]. NEUROCHEMISTRY INTERNATIONAL, 2000, 36 (06) : 523 - 530

← 1 2 3 4 5 →