Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and N→S acyl transfer

被引：14
|
作者：
Masania, Jinit [1 ]
Li, Jiejin [2 ]
Smerdon, Stephen J. [2 ]
Macmillan, Derek [1 ]
机构：
[1] UCL, Dept Chem, London WC1H 0AJ, England
[2] MRC Natl Inst Med Res, Div Mol Struct, London NW7 1AA, England
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 22期
基金：
英国医学研究理事会;
关键词：
CHEMOSELECTIVE LIGATION; EXPRESSED PROTEIN; GLYCOPEPTIDE; PEPTIDE; CHEMISTRY; GLYCOSYLATION; STRATEGIES; MECHANISM; LINKAGE; AZIDES;
D O I：
10.1039/c0ob00363h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Peptide thioesters are important tools for protein synthesis and semi-synthesis through their use in Native Chemical Ligation (NCL). NCL can be employed to assemble site-specifically modified proteins that can help elucidate the mechanisms of biomolecular processes. In this article we explore the compatibility of phosphopeptide synthesis and glycopeptide synthesis with thioester production through N -> S acyl transfer.
引用
收藏
页码：5113 / 5119
页数：7
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