Molecular characterization and response to cetuximab in a patient with refractory squamous cell anal carcinoma

被引：11
|
作者：
De Dosso, Sara [1 ]
Martin, Vittoria [2 ]
Zanellato, Elena [2 ]
Frattini, Milo [2 ]
Saletti, Piercarlo [1 ]
机构：
[1] Oncol Inst So Switzerland, CH-6500 Bellinzona, Switzerland
[2] Ist Cantonale Patol, Lab Mol Diagnost, Locarno, Switzerland
来源：
TUMORI | 2010年 / 96卷 / 04期
关键词：
anal cancer; cetuximab; EGFR; K-Ras; METASTATIC COLORECTAL-CANCER; SINGLE-AGENT; PHASE-II; IRINOTECAN; CHEMOTHERAPY;
D O I：
10.1177/030089161009600419
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
There are no standard chemotherapeutic options for patients with squamous cell anal carcinoma, relapsing and progressing on palliative cisplatin-based regimens. Similarly to other malignant conditions, monoclonal antibodies directed against the epidermal growth factor receptor may represent an attractive therapeutic strategy. Here we describe a patient who, based on molecular profile, benefited from the combination of irinotecan and cetuximab. Free full text available at www.tumorionline.it
引用
收藏
页码：627 / 628
页数：2
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