Development of a novel molecular model and the rationalisation of a series of novel inhibitors of 17a-hydroxylase/17,20-Iyase

被引：0
|
作者：
Acharya, P. [1 ]
Shahid, I. [1 ]
Owen, C. P. [1 ]
Ahmed, S. [1 ]
机构：
[1] Univ W Scotland, Sch Sci, Paisley, Renfrew, Scotland
来源：
JOURNAL OF PHARMACY AND PHARMACOLOGY | 2010年 / 62卷 / 10期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：1368 / 1368
页数：1
相关论文
共 50 条
  • [31] Novel steroidal pyrimidyl inhibitors of P450 17 (17α-hydroxylase/C17-20-lyase)
    Haidar, S
    Ehmer, PB
    Hartmann, RW
    ARCHIV DER PHARMAZIE, 2001, 334 (12) : 373 - 374
  • [32] Two rare forms of congenital adrenal hyperplasia, 11β hydroxylase deficiency and 17-hydroxylase/17,20-lyase deficiency, presenting with novel mutations
    Bulsari, Krupali
    Maple-Brown, Louise
    Falhammar, Henrik
    HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM, 2018, 17 (01): : 127 - 132
  • [33] EXPRESSION AND PURIFICATION OF FUNCTIONAL HUMAN 17-ALPHA-HYDROXYLASE/17,20-LYASE (P450C17) IN ESCHERICHIA-COLI - USE OF THIS SYSTEM FOR STUDY OF A NOVEL FORM OF COMBINED 17-ALPHA-HYDROXYLASE/17,20-LYASE DEFICIENCY
    IMAI, T
    GLOBERMAN, H
    GERTNER, JM
    KAGAWA, N
    WATERMAN, MR
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1993, 268 (26) : 19681 - 19689
  • [34] Novel P450c17 Mutation H373D Causing Combined 17α-Hydroxylase/17,20-Lyase Deficiency
    Sahakitrungruang, Taninee
    Tee, Meng Kian
    Speiser, Phyllis W.
    Miller, Walter L.
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (08): : 3089 - 3092
  • [35] 17α-hydroxylase/17,20-lyase deficiency caused by a novel homozygous mutation (Y27Stop) in the cytochrome CYP17 gene
    Müssig, K
    Kaltenbach, S
    Machicao, F
    Maser-Gluth, C
    Hartmann, MF
    Wudy, SA
    Schnauder, G
    Häring, HU
    Seif, FJ
    Gallwitz, B
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (07): : 4362 - 4365
  • [36] A Novel Compound Heterozygous Mutation of the CYP17A1 Gene Is Associated with Rhabdomyolysis: Demonstration of Combining 17α-Hydroxylase/17,20-Lyase Deficiency
    Chen, Hong
    Wang, Chunlin
    Liang, Li
    Yan, Qingfeng
    HORMONE RESEARCH IN PAEDIATRICS, 2018, 90 : 644 - 644
  • [37] Clinical, Genetic and Functional Characteristics of Three Novel CYP17A1 Mutations Causing Combined 17α-Hydroxylase/17,20-Lyase Deficiency
    Rosa, S.
    Steigert, M.
    Lang-Muritano, M.
    l'Allemand, D.
    Schoenle, E. J.
    Biason-Lauber, A.
    HORMONE RESEARCH IN PAEDIATRICS, 2010, 73 (03): : 198 - 204
  • [38] Novel P450c17 mutation H373D causing combined 17α-hydroxylase/17,20-lyase deficiency
    Sahakitrungruang, Taninee
    Tee, Meng Kian
    Speiser, Phyllis W.
    Miller, Walter L.
    HORMONE RESEARCH, 2009, 72 : 40 - 40
  • [39] Novel compound heterozygous CYP17A1 mutations identified in a family with two siblings affected by 17α-hydroxylase/17,20-lyase deficiency
    He, Rongbo
    Xu, Lin
    Yang, Nan
    Zhu, Shaoshi
    Fan, Hongqi
    Zou, Jing
    Chen, Rourou
    Qian, Li
    Liu, Yu
    STEROIDS, 2025, 214
  • [40] Neighboring group participation Part 17 Stereoselective synthesis of some steroidal 2-oxazolidones, as novel potential inhibitors of 17α-hydroxylase-C17,20-lyase
    Ondre, Dora
    Woelfling, Janos
    Ivanyi, Zoltan
    Schneider, Gyula
    Toth, Istvan
    Szecsi, Mihaly
    Julesz, Janos
    STEROIDS, 2008, 73 (14) : 1375 - 1384
12345