Metal cation induced cubic phase in poly(ethylene glycol)-functionalized dioleoylphosphatidylethanolamine aqueous dispersions

被引：11
|
作者：
Pisani, Michela [2 ]
Fino, Vincenzo [2 ]
Bruni, Paolo [2 ]
Di Cola, Emanuela
Francescangeli, Oriano [1 ]
机构：
[1] Univ Politecn Marche, Dipartimento Fis & Ingn Mat & Territorio, I-60131 Ancona, Italy
[2] Univ Politecn Marche, Dipartimento Sci & Tecnol Chim, I-60131 Ancona, Italy
来源：
JOURNAL OF PHYSICAL CHEMISTRY B | 2008年 / 112卷 / 17期
关键词：
D O I：
10.1021/jp802211r
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Metal cations (Mn2+ or Ca2+) in aqueous dispersions of mixtures of diolcoylphosphatidylethanolamine (DOPE) and poly(ethylene glycol)-functionalized DOPE (DOPE-PEG(350)) induce, above a certain amount of the PEG lipid component, a phase transition from the inverted hexagonal phase H-II to the bicontinuous inverted cubic phase Q(224) with space group Pn3m. The process is driven by the decrease of free elastic energy due to the Gaussian curvature of the cubic phase. The structural characterization of the phase behavior over the whole explored range of DOPE-PEG/DOPE weight ratio (3-25%) is reported, focusing on the role of the metal cation in the formation of the 3D cubic lattice. This result may represent a significant progress toward a design-based approach to drug delivery.
引用
收藏
页码：5276 / 5278
页数：3
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