Methionine Restriction and Cancer Biology

被引：111
|
作者：
Wanders, Desiree [1 ]
Hobson, Katherine [1 ]
Ji, Xiangming [1 ]
机构：
[1] Georgia State Univ, Byrdine F Lewis Coll Nursing & Hlth Profess, Dept Nutr, Atlanta, GA 30302 USA
来源：
NUTRIENTS | 2020年 / 12卷 / 03期
关键词：
methionine; cancer; methylation; amino acids; glutathione; TOTAL PARENTERAL-NUTRITION; HUMAN GASTRIC-CANCER; OXIDATIVE STRESS; DNA METHYLATION; LIFE-SPAN; COMPLEX I; SUPPLEMENTATION REVERSES; MOLECULAR MECHANISMS; THYMIDYLATE SYNTHASE; ROS GENERATION;
D O I：
10.3390/nu12030684
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
The essential amino acid, methionine, is important for cancer cell growth and metabolism. A growing body of evidence indicates that methionine restriction inhibits cancer cell growth and may enhance the efficacy of chemotherapeutic agents. This review summarizes the efficacy and mechanism of action of methionine restriction on hallmarks of cancer in vitro and in vivo. The review highlights the role of glutathione formation, polyamine synthesis, and methyl group donation as mediators of the effects of methionine restriction on cancer biology. The translational potential of the use of methionine restriction as a personalized nutritional approach for the treatment of patients with cancer is also discussed.
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页数：14
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