Magnesium as a Janus-faced inhibitor of calcification

被引：4
|
作者：
Nakagawa, Yosuke [1 ]
Komaba, Hirotaka [1 ,2 ,3 ]
Fukagawa, Masafumi [1 ]
机构：
[1] Tokai Univ, Sch Med, Div Nephrol Endocrinol & Metab, 143 Shimo Kasuya, Isehara, Kanagawa 2591193, Japan
[2] Tokai Univ, Sch Med, Interact Translat Res Ctr Kidney Dis, Isehara, Kanagawa, Japan
[3] Tokai Univ, Inst Med Sci, Isehara, Kanagawa, Japan
来源：
KIDNEY INTERNATIONAL | 2020年 / 97卷 / 03期
关键词：
D O I：
10.1016/j.kint.2019.11.035
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Vascular calcification is a life-threatening complication in patients with chronic kidney disease. Magnesium is a potent inhibitor of calcification and attracting attention as a new therapeutic candidate. ter Braake and colleagues demonstrate that magnesium supplementation strikingly prevents vascular calcification in Klotho knockout mice. However, these mice also show osteomalacia, indicating that magnesium has a Janus face. Maximizing the beneficial effects of magnesium without causing bone mineralization defects is an important next challenge. Copyright (C) 2020, International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：448 / 450
页数：3
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