The unique immunological and microbial aspects of pregnancy

被引：653
|
作者：
Mor, Gil [1 ]
Aldo, Paulomi [1 ]
Alvero, Ayesha B. [1 ]
机构：
[1] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, Div Reprod Sci, 333 Cedar St, New Haven, CT 06510 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2017年 / 17卷 / 08期
关键词：
REGULATORY T-CELLS; MATERNAL IMMUNE ACTIVATION; TOLL-LIKE RECEPTORS; PLACENTAL INFLAMMATORY RESPONSE; FETAL-BRAIN DEVELOPMENT; INDUCED PRETERM LABOR; ZIKA VIRUS; VIRAL-INFECTION; I INTERFERON; NK CELLS;
D O I：
10.1038/nri.2017.64
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The comparison of the immunological state of pregnancy to an immunosuppressed host-graft model continues to lead research and clinical practice to ill-defined approaches. This Review discusses recent evidence that supports the idea that immunological responses at the receptive maternal-fetal interface are not simply suppressed but are instead highly dynamic. We discuss the crucial role of trophoblast cells in shaping not only the way in which immune cells respond to the invading blastocyst but also how they collectively react to external stimuli. We also discuss the role of the microbiota in promoting a tolerogenic maternal immune system and highlight how subclinical viral infections can disrupt this status quo, leading to pregnancy complications.
引用
收藏
页码：469 / 482
页数：14
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