Construction of key building blocks towards the synthesis of cortistatins

被引：5
|
作者：
Indu, Satrajit [1 ]
Telore, Rahul D. [1 ]
Kaliappan, Krishna P. [1 ]
机构：
[1] Indian Inst Technol, Dept Chem, Mumbai 400076, Maharashtra, India
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2020年 / 18卷 / 13期
关键词：
FORMAL TOTAL-SYNTHESIS; ENYNE METATHESIS APPROACH; STEROIDAL ALKALOIDS; CONCISE SYNTHESIS; SCALABLE SYNTHESIS; CORE STRUCTURE; RING STRUCTURE; B-RING; ANGIOGENESIS; PROTECTION;
D O I：
10.1039/d0ob00170h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This work reports the construction of key building blocks towards the synthesis of cortistatins; a family of steroidal alkaloids. Cortistatin A, being a primary target due to its superior biological properties over other congeners, has been prepared by two different synthetic routes. Synthesis of the precursor to the heavily substituted A-ring starting from d-glucose and construction of the DE-ring junction employing a Hajos-Parrish ketone as a chiral pool have been demonstrated. Efforts are underway to assemble these key fragments and build towards the total synthesis of cortistatin A.
引用
收藏
页码：2432 / 2446
页数：15
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