Construction of key building blocks towards the synthesis of cortistatins

被引：5

作者：

Indu, Satrajit ^{[1
]}

Telore, Rahul D. ^{[1
]}

Kaliappan, Krishna P. ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Mumbai 400076, Maharashtra, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2020年 / 18卷 / 13期

关键词：

FORMAL TOTAL-SYNTHESIS; ENYNE METATHESIS APPROACH; STEROIDAL ALKALOIDS; CONCISE SYNTHESIS; SCALABLE SYNTHESIS; CORE STRUCTURE; RING STRUCTURE; B-RING; ANGIOGENESIS; PROTECTION;

D O I：

10.1039/d0ob00170h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This work reports the construction of key building blocks towards the synthesis of cortistatins; a family of steroidal alkaloids. Cortistatin A, being a primary target due to its superior biological properties over other congeners, has been prepared by two different synthetic routes. Synthesis of the precursor to the heavily substituted A-ring starting from d-glucose and construction of the DE-ring junction employing a Hajos-Parrish ketone as a chiral pool have been demonstrated. Efforts are underway to assemble these key fragments and build towards the total synthesis of cortistatin A.

引用

页码：2432 / 2446

页数：15

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