Peripheral administration of poly I:C disrupts contextual fear memory consolidation and BDNF expression in mice

被引：18
|
作者：
Kranjac, Dinko [1 ]
McLinden, Kristina A. [1 ]
Koster, Kyle M. [1 ]
Kaldenbach, David L. [1 ]
Chumley, Michael J. [2 ]
Boehm, Gary W. [1 ]
机构：
[1] Texas Christian Univ, Dept Psychol, Ft Worth, TX 76129 USA
[2] Texas Christian Univ, Dept Biol, Ft Worth, TX 76129 USA
来源：
BEHAVIOURAL BRAIN RESEARCH | 2012年 / 228卷 / 02期
关键词：
Polyinosinic polycytidylic acid; Memory; Consolidation; Cytokines; Brain-derived neurotrophic factor; DOUBLE-STRANDED-RNA; IMMUNE ACTIVATION; NEUROTROPHIC FACTOR; SYSTEMIC CHALLENGE; SICKNESS BEHAVIOR; LIPOPOLYSACCHARIDE; BRAIN; HIPPOCAMPUS; IL-1-BETA; MECHANISMS;
D O I：
10.1016/j.bbr.2011.12.031
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
In the current study, administration of poly I:C induced a deficit in contextual, but not auditory-cue, fear memory consolidation. This memory deficit coincided with a decrease in hippocampal and cortical BDNF mRNA expression. These results extend prior work, and suggest that a single peripheral injection of poly I:C disrupts contextual fear memory consolidation processes in adult mice, and that these deficits may potentially be mediated by diminished BDNF expression. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：452 / 457
页数：6
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