Peripheral administration of poly I:C disrupts contextual fear memory consolidation and BDNF expression in mice

被引：18

作者：

Kranjac, Dinko ^{[1
]}

McLinden, Kristina A. ^{[1
]}

Koster, Kyle M. ^{[1
]}

Kaldenbach, David L. ^{[1
]}

Chumley, Michael J. ^{[2
]}

Boehm, Gary W. ^{[1
]}

机构：

[1] Texas Christian Univ, Dept Psychol, Ft Worth, TX 76129 USA

[2] Texas Christian Univ, Dept Biol, Ft Worth, TX 76129 USA

来源：

BEHAVIOURAL BRAIN RESEARCH | 2012年 / 228卷 / 02期

关键词：

Polyinosinic polycytidylic acid; Memory; Consolidation; Cytokines; Brain-derived neurotrophic factor; DOUBLE-STRANDED-RNA; IMMUNE ACTIVATION; NEUROTROPHIC FACTOR; SYSTEMIC CHALLENGE; SICKNESS BEHAVIOR; LIPOPOLYSACCHARIDE; BRAIN; HIPPOCAMPUS; IL-1-BETA; MECHANISMS;

D O I：

10.1016/j.bbr.2011.12.031

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

In the current study, administration of poly I:C induced a deficit in contextual, but not auditory-cue, fear memory consolidation. This memory deficit coincided with a decrease in hippocampal and cortical BDNF mRNA expression. These results extend prior work, and suggest that a single peripheral injection of poly I:C disrupts contextual fear memory consolidation processes in adult mice, and that these deficits may potentially be mediated by diminished BDNF expression. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：452 / 457

页数：6

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