Malignant mixed Mullerian tumor of the fallopian tube: Case report and literature review

被引:2
|
作者
Cozlea, Alexandra Lavinia [1 ]
Gheorghe, Mihai [1 ]
Kiss, Szilard Leo [1 ]
Fandi, Anas [1 ]
Stanca, Mihai [1 ]
Mocan, Simona [2 ]
Capilna, Mihai Emil [1 ]
Bacalbasa, Nicolae [3 ]
Moldovan, Andreea Anamaria [4 ]
机构
[1] George Emil Palade Univ Med Pharm Sci & Technol, Obstet & Gynecol Clin 1, 50 Gheorghe Marinescu St, Targu Mures 540136, Romania
[2] George Emil Palade Univ Med Pharm Sci & Technol, Dept Pathol, 540136 Targu Mure, Targu Mures 540136, Romania
[3] Carol Davila Univ Med & Pharm, Dept Obstet & Gynecol, Bucharest 020022, Romania
[4] Brasov Cty Emergency Hosp, Dept Infect Dis, Brasov 500326, Romania
关键词
fallopian tube; carcinosarcoma; surgery; chemotherapy; omentectomy; lymphadenectomy; MESODERMAL TUMOR; UTERINE TUBE; 5-YEAR SURVIVAL; PHASE-II; CARCINOSARCOMA; CHEMOTHERAPY; PACLITAXEL; CARBOPLATIN; CARCINOMA; SURGERY;
D O I
10.3892/etm.2021.11100
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Carcinosarcoma, also known as malignant mixed Mullerian tumor (MMMT), includes both malignant epithelial and mesenchymal elements. While the endometrium is the most frequent known site for carcinosarcomas, their development in the fallopian tube is rare condition, only accounting for 0.1 to 0.5% among all gynecological malignancies. Fallopian tube MMMT is associated with an aggressive progression. A total of 94 previous case reports were reviewed and divided, after applying the exclusion criteria, into 2 groups: No evidence of disease (NED) Group including 33 patients reported to be without any residual disease at the end of the follow-up period; death of disease (DOD) Group including 51 patients who died due to the progression of fallopian carcinosarcoma or its complications. The gathered data were statistically analyzed together with a case from our clinical experience: a 65-year-old postmenopausal patient with a final histological diagnosis of fallopian carcinosarcoma staged FIGO IC2, synchronous with a serous endometrial intraepithelial carcinoma. Patient age between 41 and 60 years, symptoms at presentation and computed tomography (CT)/magnetic resonance imaging (MRI) tumor evidence are prognostic factors (P<0.05). Omentectomy [odds ratio (OR)=0.3545] and pelvic lymphadenectomy (OR=0.3732) were found to be significant factors for survival (P<0.05). Fimbrial localization of the tumor is a negative prognosis factor (OR=4.263), as well as the heterologous type of tumor (OR=2.880). Chemotherapy was found to improve survival (OR=0.2679) while radiotherapy had no influence on patient prognosis. Reporting these rare cases could be essential for obtaining more precise information regarding the treatment and prognosis of patients with MMMT of the fallopian tube, in order to improve patient survival and quality of life.
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页数:11
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