Evaluation of the bactericidal and trypanocidal activities of triterpenes isolated from the leaves, stems, and flowers of Lychnophora pinaster

被引：25
|
作者：
Abreu, Viviane G. C. [1 ]
Takahashi, Jacqueline A. [1 ]
Duarte, Lucienir P. [1 ]
Pilo-Veloso, Dorila [1 ]
Junior, Policarpo A. S. [2 ]
Alves, Rosana O. [2 ]
Romanha, Alvaro J. [1 ,2 ]
Alcantara, Antonio F. C. [1 ]
机构：
[1] Univ Fed Minas Gerais, Inst Ciencias Exatas, Dept Quim, BR-31260901 Belo Horizonte, MG, Brazil
[2] Ctr Pesquisas Rene Rachou Fiocruz, Lab Parasitol Celular & Mol, Rio De Janeiro, Brazil
来源：
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2011年 / 21卷 / 04期
关键词：
Lychnophora pinaster; triterpenes; bactericidal activity; trypanocidal activity; VERNONIEAE; ASTERACEAE;
D O I：
10.1590/S0102-695X2011005000095
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The phytochemical investigation on the aereal parts of Lychnophora pinaster Mart., Asteraceae, was carried to isolation of triterpenes. 3-O-Acetyl-lupeol (1), 3-O-acetyl-pseudotaraxasterol (2), and 3-O-acetyl-alpha-amyrin (3) were isolated from hexanic extract and 4,4-dimethyl-cholesta-22,24-dien-5-ol (4), a-amyrin (5), and lupeol (6) were isolated from hexanic/dichlorometanic extract of the leaves. Compounds Delta(7)-bauerenyl acetate (7), friedelin (8), stigmasterol (9), and sitosterol (10) were isolated from the hexanic/dichlorometanic extract of the stems. The steroids 9 and 10 were also isolated from the hexanic/dichlorometanic extract of the flowers. Triterpenes 1, 3, 4, and 7 are described for the first time in the genus Lychnophora. The apolar fractions of the leaf and stem extracts and some isolated triterpenes showed low trypanocidal activity. Moreover, apolar fractions of the leaf and stem extracts and 5 showed antibacterial action against Staphylococcus aureus.
引用
收藏
页码：615 / 621
页数：7
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