Extensively-drug resistant Acinetobacter baumannii bacteremia in neonates: effective treatment with the combination of colistin and ampicillin/sulbactam

被引：5
|
作者：
Gkentzi, Despoina [1 ]
Tsintoni, Asimina [1 ]
Christopoulou, Irini [1 ]
Mamalis, Ilias [1 ]
Paliogianni, Fotini [2 ]
Assimakopoulos, Stelios F. [3 ]
Marangos, Markos [3 ]
Dimitriou, Gabriel [1 ]
机构：
[1] Univ Gen Hosp Patras, Patras Med Sch, Dept Pediat, Rion, Greece
[2] Univ Gen Hosp Patras, Patras Med Sch, Dept Microbiol, Rion, Greece
[3] Univ Gen Hosp Patras, Patras Med Sch, Dept Infect Dis, Rion, Greece
来源：
JOURNAL OF CHEMOTHERAPY | 2020年 / 32卷 / 02期
关键词：
Extensively-drug resistant; Acinetobacter baumannii; neonates; colistin; ampicillin; sulbactam; ENTEROBACTERIACEAE; INFECTIONS;
D O I：
10.1080/1120009X.2020.1716478
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Acinetobacter baumannii has evolved as a major pathogen of outbreaks in the healthcare setting with increased morbidity and mortality. In neonates, treatment can be quite challenging due to the resistance profile of A. baumannii as well as limited data on pharmakokinetics and pharmakodynamics of antibiotics in this age group. We present an outbreak of eight cases of extensively-drug resistant (XDR) A. baumannii bacteremias successfully managed with the combination of colistin with high dose ampicillin/sulbactam.
引用
收藏
页码：103 / 106
页数：4
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