The Drosophila circadian clock:: what we know and what we don't know

被引：17
|
作者：
Blau, J [1 ]
机构：
[1] NYU, Dept Biol, New York, NY 10003 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2001年 / 12卷 / 04期
关键词：
dClock; double-time; Drosophila; period;
D O I：
10.1006/scdb.2001.0256
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Circadian rhythms are regulated by endogenous body clerks, which are formed by rhythmic cycles of clock gene expression. Almost all reviews of the Drosophila circadian clock state that the intracellular oscillator is based on a simple negative feedback loop. However, net many 'simple' feedback loops in biology last for 24 h. Instead, the Drosophila clock is a series of precisely timed steps that are deliberately slow In this paper, I will discuss the current model for how the Drosophila clock is regulated and ask what questions remain to be answered.
引用
收藏
页码：287 / 293
页数：7
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