Autologous hematopoietic cells for severe autoimmune diseases: Guidelines of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) for immune monitoring and biobanking

被引：2

作者：

Lansiaux, Pauline ^{[1
,2
]}

Loisel, Severine ^{[3
]}

Castilla-Llorente, Cristina ^{[4
]}

Fontenille, Claire ^{[5
]}

Kabdani, Sarah ^{[6
]}

Marjanovic, Zora ^{[7
]}

Pugnet, Gregory ^{[8
]}

Puyade, Mathieu ^{[9
,10
]}

Robert, Emilie ^{[5
]}

Terriou, Louis ^{[11
]}

Abdallah, Nassim Ait ^{[1
,2
]}

Maria, Alexandre Thibault Jacques ^{[12
]}

Michel, Laure ^{[13
]}

Treton, Xavier ^{[14
]}

Yakoub-Agha, Ibrahim ^{[15
]}

Farge, Dominique ^{[1
,2
,16
]}

机构：

[1] Hop St Louis, AP HP, Unite Med Interne UF 04 CRMR MATHEC, Malad Autoimmunes & Therapie Cellulaire,Ctr Refer, F-75010 Paris, France

[2] Univ Paris, Inst Rech St Louis, Rech Clin Appl Hematol, EA3518, F-75010 Paris, France

[3] CHU Rennes, Etab Francais Sang Bretagne, SITI, F-35000 Rennes, France

[4] Gustave Roussy Canc Ctr, Dept Hematol, 114 Rue Edouard Vaillant, F-94800 Villejuif, France

[5] Assoc CRYOSTEM, Inst Paoli Calmettes, F-13009 Marseille, France

[6] EFS HFNO Site Lille, Unite Therapie Cellulaire, Part Eurasante,20,Ave Pierre Mauroy, F-59373 Loos, France

[7] Hop St Antoine, AP HP, Serv Hematol, 184 Rue Faubourg St Antoine, F-75012 Paris, France

[8] CHU Rangueil, Serv Med Interne & Immunol Clin, 1 Ave Prof Jean Poulhes, F-31059 Toulouse 9, France

[9] CHU Poitiers, Serv Med Interne, 2 Rue Miletrie, F-86021 Poitiers, France

[10] CHU Poitiers, CIC 1402, 2 Rue Miletrie, F-86021 Poitiers, France

[11] CHRU Lille, Hop Claude Huriez, Serv Med Interne & Immunol Clin, Rue Michel Polonovski, F-59000 Lille, France

[12] CHRU Montpellier, Hop St Eloi, Med Interne Malad Multiorgan Adulte, Inserm U1183 IRMB, F-34295 Montpellier 5, France

[13] CHU Rennes, Serv Neurol, Rennes, France

[14] Univ Paris, Hop Beaujon, Serv Gastroenterol, MICI & Assistance Nutrit,DMU DIGEST, 100 Blvd Leclerc, F-92110 Clichy, France

[15] Univ Lille, Inserm U995, LIRIC, CHU Lille, F-59000 Lille, France

[16] McGill Univ, Dept Med, Montreal, PQ H3A 1A1, Canada

来源：

BULLETIN DU CANCER | 2021年 / 108卷 / 12期

关键词：

Autoimmune diseases; Autologous hematopoietic; cell transplantation; Immune reconstitution; Post-transplantation; immune follow-up; Biobanking; SYSTEMIC-SCLEROSIS; MULTIPLE-SCLEROSIS; REPERTOIRE; BLOOD; SCT; EVOLUTION; JUVENILE; OUTCOMES; HSCT;

D O I：

10.1016/j.bulcan.2021.03.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Autologous hematopoietic cell transplantation (AHCT) is a new treatment option for patients with severe autoimmune diseases (AD), based on the use of intensive or myeloablative chemotherapy to eradicate the pathogenic autoreactive immune cells and to allow the installation of a new and tolerant immune system during immune reconstitution process. Immune reconstitution analysis after AHCT is required for patients clinical follow-up and to further identify biological and immunological markers of the clinical response to develop individualized AHCT protocols. These MATHEC-SFGM-TC good clinical practice guidelines were developed by a multidisciplinary group of experts including members of the french reference center for stem Cell Therapy in Auto-immune Diseases (MATHEC), hematologists from the French speaking Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) and experts in immune monitoring and biobanking. The objectives are to provide practical recommandations for immune monitoring and biobanking of samples in patients with AD undergoing AHCT, for routine care purposes and investigational studies.

引用

页码：S72 / S81

页数：10

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