Preliminary in vitro study of anti-oxidant activity and anti-diabetic potential of plant extracts from 4 herbal substances not traditionally used for treatment of diabetes mellitus

被引:3
|
作者
Trifonova, Dora [1 ]
Gavrilova, Anna [2 ]
Dyakova, Galina [2 ]
Gavrilov, Genadi [2 ]
Yotova, Maya [2 ]
Nikolov, Stefan [2 ]
机构
[1] Med Univ Pleven, Fac Pharm, Dept Phys Biophys Preclin & Clin Sci, Pleven, Bulgaria
[2] Med Univ Pleven, Fac Pharm, Dept Pharmaceut Chem & Pharmacognosy, Pleven, Bulgaria
关键词
medicinal plants; water extracts; DPPH; ABTS; alpha-glucosidase inhibitory activity; SATUREJA-MONTANA L; WIERZB. EX HEUFF; CICHORIUM-INTYBUS; OXIDATIVE STRESS; DIETARY POLYPHENOLS; LIPID-PEROXIDATION; PHENOLIC-COMPOUNDS; ALPHA-GLUCOSIDASE; ESSENTIAL OILS; VARIABILITY;
D O I
10.3897/pharmacia.68.e72769
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The focus of the presented study is the in vitro anti-oxidant activity and anti-diabetic potential of water extracts from the following four herbal substances, not traditionally used for treatment of diabetes mellitus - leaves of Sambucus ebulus L. and Prunus mahaleb L., and flowering stems of Cichorium intybus L. and Satureja kitaibelii Wierzb. ex Heuff. The water extracts are obtained through ultrasonication. The extract of S. kitaibelii stands out due to its highest values in all studied indicators - total phenolic content, scavenging potential (DPPH, ABTS) and alpha-glucosidase inhibitory activity which was six times higher than acarbose. The extract of C. intybus also showed significant alpha-glucosidase inhibitory activity compared to acarbose. The flowering stems of both species are promising sources of biologically active substances for blood sugar control in diabetes mellitus.
引用
收藏
页码:755 / 762
页数:8
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