Preliminary in vitro study of anti-oxidant activity and anti-diabetic potential of plant extracts from 4 herbal substances not traditionally used for treatment of diabetes mellitus

被引:3
|
作者
Trifonova, Dora [1 ]
Gavrilova, Anna [2 ]
Dyakova, Galina [2 ]
Gavrilov, Genadi [2 ]
Yotova, Maya [2 ]
Nikolov, Stefan [2 ]
机构
[1] Med Univ Pleven, Fac Pharm, Dept Phys Biophys Preclin & Clin Sci, Pleven, Bulgaria
[2] Med Univ Pleven, Fac Pharm, Dept Pharmaceut Chem & Pharmacognosy, Pleven, Bulgaria
关键词
medicinal plants; water extracts; DPPH; ABTS; alpha-glucosidase inhibitory activity; SATUREJA-MONTANA L; WIERZB. EX HEUFF; CICHORIUM-INTYBUS; OXIDATIVE STRESS; DIETARY POLYPHENOLS; LIPID-PEROXIDATION; PHENOLIC-COMPOUNDS; ALPHA-GLUCOSIDASE; ESSENTIAL OILS; VARIABILITY;
D O I
10.3897/pharmacia.68.e72769
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The focus of the presented study is the in vitro anti-oxidant activity and anti-diabetic potential of water extracts from the following four herbal substances, not traditionally used for treatment of diabetes mellitus - leaves of Sambucus ebulus L. and Prunus mahaleb L., and flowering stems of Cichorium intybus L. and Satureja kitaibelii Wierzb. ex Heuff. The water extracts are obtained through ultrasonication. The extract of S. kitaibelii stands out due to its highest values in all studied indicators - total phenolic content, scavenging potential (DPPH, ABTS) and alpha-glucosidase inhibitory activity which was six times higher than acarbose. The extract of C. intybus also showed significant alpha-glucosidase inhibitory activity compared to acarbose. The flowering stems of both species are promising sources of biologically active substances for blood sugar control in diabetes mellitus.
引用
收藏
页码:755 / 762
页数:8
相关论文
共 48 条
  • [1] ISOLATION, CHARACTERIZATION OF Β-SITOSTEROL FROM THE HERBAL EXTRACTS AND EVALUATION OF IN VITRO ANTI-OXIDANT AND ANTI-DIABETIC ACTIVITIES
    Gomathi, S.
    Maneemegalai, S.
    [J]. JOURNAL OF MICROBIOLOGY BIOTECHNOLOGY AND FOOD SCIENCES, 2023,
  • [2] ISOLATION, CHARACTERIZATION OF B-SITOSTEROL FROM THE HERBAL EXTRACTS AND EVALUATION OF IN VITRO ANTI-OXIDANT AND ANTI-DIABETIC ACTIVITIES
    Gomathi, S.
    Maneemegalai, S.
    [J]. JOURNAL OF MICROBIOLOGY BIOTECHNOLOGY AND FOOD SCIENCES, 2024, 13 (04):
  • [3] In Vitro Anti-Diabetic and Anti-Oxidant Activities of Geum Species from Iran
    Farzaneh, Avishan
    Faramarzi, Mohammad Ali
    Delnavazi, Mohammad Reza
    Monsef-Esfahani, Hamid Reza
    Adhami, Hamid Reza
    [J]. RESEARCH JOURNAL OF PHARMACOGNOSY, 2022, 9 (02) : 37 - 44
  • [4] In vitro and in vivo anti-diabetic and anti-oxidant activities of methanolic leaf extracts of Ocimum canum
    Ononamadu, Chimaobi J.
    Alhassan, Adamu J.
    Imam, Abdullahi A.
    Ibrahim, Aminu
    Iheghoro, Godwin O.
    Owolarafe, Alowonle T.
    Sule, Mohammed S.
    [J]. CASPIAN JOURNAL OF INTERNAL MEDICINE, 2019, 10 (02) : 162 - 175
  • [5] Anti-glycating and anti-oxidant compounds from traditionally used anti-diabetic plantGeigeria alata(DC) Oliv. & Hiern.
    Fadul, Eltayeb
    Nizamani, Arsalan
    Rasheed, Saima
    Adhikari, Achyut
    Yousuf, Sammer
    Parveen, Shahida
    Goren, Nezhun
    Alhazmi, Hassan A.
    Choudhary, M. Iqbal
    Khalid, Asaad
    [J]. NATURAL PRODUCT RESEARCH, 2020, 34 (17) : 2456 - 2464
  • [6] Potential anti-diabetic and anti-oxidant activity of essential oil of Zataria multiflora leaves
    Kamrani, Y. Y.
    Amanlou, M.
    Yazdanyar, A.
    AdliMoghaddam, A.
    Ebrahimi, S. N.
    [J]. PLANTA MEDICA, 2008, 74 (09) : 982 - 982
  • [7] Anti-Diabetic and Anti-Oxidant Activity of Leaf and Bark Extracts of Murraya koenigii on Streptozotocine Induced Diabetic Rats
    Sahu, P. K.
    Jena, R. C.
    Jena, S.
    Panda, A.
    Bhol, R.
    [J]. ASIAN JOURNAL OF CHEMISTRY, 2013, 25 (12) : 6591 - 6596
  • [8] Anti-Oxidant Activity of Different Herbal Extracts Used in Traditional Chinese Medicine for the Treatment of Cardiovascular Disease
    Wang, Meiqi
    Wang, Shaozhao
    Goel, Vinti
    Ling, Lei
    Shan, Jacqueline
    [J]. PHARMACEUTICAL BIOLOGY, 2010, 48 : 29 - 30
  • [9] Anti-Diabetic, Anti-Inflammatory, and Anti-Oxidant Effects of Naringenin in an In Vitro Human Model and an In Vivo Murine Model of Gestational Diabetes Mellitus
    Nguyen-Ngo, Caitlyn
    Willcox, Jane C.
    Lappas, Martha
    [J]. MOLECULAR NUTRITION & FOOD RESEARCH, 2019, 63 (19)
  • [10] α-amylase inhibitors extracted from plants traditionally used for diabetes and their potential as novel anti-diabetic treatments
    Bawden-Tucknott, K.
    Raman, A.
    Hylands, P. J.
    Houghton, P. J.
    [J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 2004, 56 : S81 - S81