A closed-loop optimal control of the plasma glycemia

被引：2
|
作者：
Palumbo, Pasquale [1 ]
De Gaetano, Andrea [1 ]
机构：
[1] IASI CNR, Ist Anal Sistemi & Informat A Ruberti, I-00185 Rome, Italy
来源：
PROCEEDINGS OF THE 45TH IEEE CONFERENCE ON DECISION AND CONTROL, VOLS 1-14 | 2006年
关键词：
glucose-insulin system; exact feedback linearization; optimal control;
D O I：
10.1109/CDC.2006.377737
中图分类号：
TP [自动化技术、计算机技术];
学科分类号：
0812 ;
摘要：
The paper investigates the problem of the optimal tracking of a desired plasma glucose evolution by means of a continuous intravenous infusion. The model for the glucose-insulin system here adopted, and recently published, belongs to the class of nonlinear single-distributed delay models. The closed-loop control law is performed according to the feedback linearization theory: a state-feedback is designed in order to exactly linearize the model with respect to a suitably defined change of coordinates. Then, the optimal tracking is achieved by minimizing a performance index. The methodology here proposed allows both to decrease and increase the glycemia. Simulations support theoretical results and show the physical reliability of the approach proposed.
引用
收藏
页码：679 / 684
页数：6
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