A unique immuno-stimulant steroidal sapogenin acid from the roots of Asparagus racemosus

被引：17
|
作者：
Sharma, Punita [1 ]
Chauhan, Prashant S. [2 ]
Dutt, Prabhu [1 ]
Amina, Musarat [1 ]
Suri, Krishan A. [1 ]
Gupta, Bishan D. [1 ]
Suri, Om P. [1 ]
Dhar, Kanaya L. [1 ]
Sharma, Deepak [3 ]
Gupta, Vivek [3 ]
Satti, Naresh K. [1 ]
机构：
[1] CSIR, Nat Prod Chem Plants Div, Indian Inst Integrat Med, Jammu 180001, J And K, India
[2] CSIR, Cell Biol Lab, Div Pharmacol, Indian Inst Integrat Med, Jammu 180001, J And K, India
[3] Univ Jammu, Postgrad Dept Phys, Jammu 180006, J And K, India
来源：
STEROIDS | 2011年 / 76卷 / 04期
关键词：
Asparagus racemosus; Steroidal sapogenin; X-ray crystallography; Restraint stress; Immunostimulation; Cyclosporin-A; SARSASAPOGENIN; MICE;
D O I：
10.1016/j.steroids.2010.12.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new steroidal sapogenin molecule 1 having unique characteristics, 21-nor and unusual C19 carboxylic acid has been isolated from the roots of Asparagus racemosus. On the basis of chemical evidence, extensive spectroscopic analysis including two dimensional (2D) NMR and X-ray studies of single crystal, the structure of 1 was determined as (1S,2R,3S.8S,9S,10S,13S,14S,16S,17R,22R,25R)-21-nor-18 beta,27 alpha-dimethyl-1 beta.2 beta,3 beta-trihydroxy-25-spirost-4-en-19 beta-oic acid. 1 crystallizes in monoclinic space group P2(1) with a=9.295(2), b = 11.238(2), c = 11.376(2)angstrom; beta = 91.993(4), Z = 2, D(cal) = 1.344 Mg/m(3). The structure was solved by direct methods and refined by full-matrix least-squares procedure to a final R-value of 0.0561 for 4064 observed reflections. 1 was tested against the type of immune responses generated during treatment in normal and immune-suppressed animals and detailed biological activity evaluation suggests it to be a potent immunostimulator. (C) 2010 Elsevier Inc. All rights reserved.
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收藏
页码：358 / 364
页数：7
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