A unique immuno-stimulant steroidal sapogenin acid from the roots of Asparagus racemosus

被引：17

作者：

Sharma, Punita ^{[1
]}

Chauhan, Prashant S. ^{[2
]}

Dutt, Prabhu ^{[1
]}

Amina, Musarat ^{[1
]}

Suri, Krishan A. ^{[1
]}

Gupta, Bishan D. ^{[1
]}

Suri, Om P. ^{[1
]}

Dhar, Kanaya L. ^{[1
]}

Sharma, Deepak ^{[3
]}

Gupta, Vivek ^{[3
]}

Satti, Naresh K. ^{[1
]}

机构：

[1] CSIR, Nat Prod Chem Plants Div, Indian Inst Integrat Med, Jammu 180001, J And K, India

[2] CSIR, Cell Biol Lab, Div Pharmacol, Indian Inst Integrat Med, Jammu 180001, J And K, India

[3] Univ Jammu, Postgrad Dept Phys, Jammu 180006, J And K, India

来源：

STEROIDS | 2011年 / 76卷 / 04期

关键词：

Asparagus racemosus; Steroidal sapogenin; X-ray crystallography; Restraint stress; Immunostimulation; Cyclosporin-A; SARSASAPOGENIN; MICE;

D O I：

10.1016/j.steroids.2010.12.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new steroidal sapogenin molecule 1 having unique characteristics, 21-nor and unusual C19 carboxylic acid has been isolated from the roots of Asparagus racemosus. On the basis of chemical evidence, extensive spectroscopic analysis including two dimensional (2D) NMR and X-ray studies of single crystal, the structure of 1 was determined as (1S,2R,3S.8S,9S,10S,13S,14S,16S,17R,22R,25R)-21-nor-18 beta,27 alpha-dimethyl-1 beta.2 beta,3 beta-trihydroxy-25-spirost-4-en-19 beta-oic acid. 1 crystallizes in monoclinic space group P2(1) with a=9.295(2), b = 11.238(2), c = 11.376(2)angstrom; beta = 91.993(4), Z = 2, D(cal) = 1.344 Mg/m(3). The structure was solved by direct methods and refined by full-matrix least-squares procedure to a final R-value of 0.0561 for 4064 observed reflections. 1 was tested against the type of immune responses generated during treatment in normal and immune-suppressed animals and detailed biological activity evaluation suggests it to be a potent immunostimulator. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：358 / 364

页数：7

共 38 条

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Hayes, Patricia Y.
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[2] Steroidal saponins from the roots of Asparagus adscendens Roxb and Asparagus racemosus Willd
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[3] Steroidal Saponins from Asparagus racemosus
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[4] Steroidal saponins from the fruits of Asparagus racemosus
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[8] Furostanol Saponin and Diphenylpentendiol from the Roots of Asparagus racemosus
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[9] New Ursane Glycoside from the Roots of Asparagus racemosus
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[10] Hepatoprotective and immuno-stimulant effects of nutaceutical compounds from carteonoid origin
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PLANTA MEDICA, 2007, 73 (09) : 961 - 961

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