A facile synthesis and some new reactions of N-benzylcarboxamides with essential amino acids

被引：0
|
作者：
El-Sayed, RA [1 ]
机构：
[1] Al Azhar Univ, Fac Sci, Dept Chem, Nasr City, Cairo, Egypt
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1998年 / 37卷 / 10期
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D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
N-Benzyl-p-chloro and N-benzyl-2, 4-dichlorobenzamide react with chlorosulfonic acid to give the corresponding p-sulfonyl chlorides 1, 19, which on condensation with nucleophiles give amino acid derivatives 2-7 and 20-25. Some of the corresponding methyl esters 8-11 are also prepared. Hydrazinolysis of these methyl esters yield the hydrazides 12-15. Coupling reactions of some amino acid derivatives with amino acid methyl ester hydrochloride in THF-Et3N medium using the dicyclohexylcarbodiimide method famishes the desired dipeptide methyl esters 16-18, 26-28. The spectral data are briefly discussed.
引用
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页码：1059 / 1062
页数：4
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