Altered retinoic acid receptors

被引：48

作者：

deThe, H ^{[1
]}

机构：

[1] HOP ST LOUIS,SERV BIOCHIM,F-75475 PARIS 10,FRANCE

来源：

FASEB JOURNAL | 1996年 / 10卷 / 09期

关键词：

leukemia; dominant-negative; transcription nuclear bodies;

D O I：

10.1096/fasebj.10.9.8801177

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Structurally and functionally altered retinoic acid receptors have been associated with rare human neoplasms: acute promyelocytic leukemia and hepatocellular carcinoma, Whereas the retinoic acid receptor beta (RAR beta) rearrangement in hepatocellular carcinoma is unique, in acute promyelocytic leukemia (APL), RAR alpha fusion to the promyelocytic leukemia (PML) gene by the t(15;11) translocation is a general feature of the disease, APL is an important model in cancer biology because retinoic acid induces complete remissions in this malignancy, providing the first example of differentiation therapy and of an antineoplastic drug directly targeted at the underlying genetic lesion, The molecular basis of PML/RAR alpha fusion leukemogenesis is discussed with respect to dominant negative inhibition of nuclear receptor and PML functions.

引用

页码：955 / 960

页数：6

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