Synthesis of Benzofuran Derivatives via Rearrangement and Their Inhibitory Activity on Acetylcholinesterase

被引：10

作者：

Zhou, Xiang ^{[1
]}

Li, Miao ^{[2
]}

Wang, Xiao-Bing ^{[1
]}

Wang, Tao ^{[2
]}

Kong, Ling-Yi ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 210009, Peoples R China

[2] China Pharmaceut Univ, Jiangsu Ctr Drug Screening, Nanjing 210009, Peoples R China

来源：

MOLECULES | 2010年 / 15卷 / 12期

关键词：

coumarin; benzofuran; rearrangement; anti-AChE; ALZHEIMERS-DISEASE; 3-DIMENSIONAL STRUCTURE; TORPEDO-CALIFORNICA; AGGREGATION; PEPTIDE; COMPLEX; DESIGN; E2020;

D O I：

10.3390/molecules15128593

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During a synthesis of coumarins to obtain new candidates for treating Alzheimer's Disease (AD), an unusual rearrangement of a benzopyran group to a benzofuran group occurred, offering a novel synthesis pathway of these benzofuran derivatives. The possible mechanism of the novel rearrangement was also discussed. All of the benzofuran derivatives have weak anti-AChE activities compared with the reference compound, donepezil.

引用

页码：8593 / 8601

页数：9

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