Novel benzofuran derivatives: synthesis and antitumor activity

被引：10
|
作者：
Othman, Dina I. [1 ]
Abdelal, Ali M. M. [1 ]
El-Sayed, Magda A. [1 ]
El Bialy, Serry A. A. [1 ]
机构：
[1] Univ Mansoura, Fac Pharm, Dept Organ Pharmaceut Chem, Mansoura 35516, Egypt
来源：
HETEROCYCLIC COMMUNICATIONS | 2013年 / 19卷 / 01期
关键词：
antitumor activity; benzofuran; HEPG2; one-pot reaction; thiazolidin-4-one; ANTICANCER;
D O I：
10.1515/hc-2012-0119
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of new benzofuran derivatives 3a-f, 5a-e containing a heterocyclic substituent linked to benzofuran nucleus at C-2 were synthesized as potential antitumor agents. These products were synthesized starting with 2-bromoacetylbenzofuran 1. The structures of all compounds were established on the basis of analytical and spectral data. The synthesized compounds were tested against human liver carcinoma cell line (HEPG2) and all were more potent than the comparative standard (5-flurouracil). Compound 3f was the most active (IC50 = 12.4 mu g/mL).
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收藏
页码：29 / 35
页数：7
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