Synthesis and antitumor activity of novel distamycin derivatives

被引：20

作者：

Baraldi, PG ^{[1
]}

Beria, I ^{[1
]}

Cacciari, B ^{[1
]}

Cozzi, P ^{[1
]}

Franzetti, C ^{[1
]}

Mongelli, N ^{[1
]}

Romagnoli, R ^{[1
]}

Spalluto, G ^{[1
]}

机构：

[1] PHARMACIA & UPJOHN, ONCOL PRECLIN RES, MILAN, ITALY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 11期

关键词：

D O I：

10.1016/0960-894X(96)00204-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several distamycin derivatives were synthesized from deformyl distamycin by coupling with different azole carboxylic acids bearing an alkylating moiety. Some of them showed good activities in vitro and in vivo against L 1210 murine leukemia. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1241 / 1246

页数：6

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