Pd-catalyzed dehydrogenative annulation approach for the efficient synthesis of phenanthridinones

被引：70

作者：

Li, Xinyao ^{[1
]}

Pan, Jun ^{[1
]}

Song, Song ^{[1
]}

Jiao, Ning ^{[1
,2
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Xue Yuan Rd 38, Beijing 100191, Peoples R China

[2] Nankai Univ, State Key Lab Elementoorgan Chem, Weijin Rd 94, Tianjin 300071, Peoples R China

来源：

CHEMICAL SCIENCE | 2016年 / 7卷 / 08期

基金：

中国国家自然科学基金;

关键词：

CATELLANI ORTHO-ARYLATION; H BOND ACTIVATION; C-H; ARYL IODIDES; N-METHOXYBENZAMIDES; SIMPLE ANILINES; INDOLES; CASCADE; ALKYNES; ARENES;

D O I：

10.1039/c6sc01148a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel Pd-catalyzed intermolecular dehydrogenative annulation of aryl iodides and aryl carbamic chlorides for the efficient synthesis of phenanthridinone derivatives was developed. Simple aryl iodides and carbamic chlorides readily made from various anilines, a broad substrate scope with hetero/polycycles, as well as high-value products, make this direct dehydrogenative annulation approach very practical and attractive.

引用

页码：5384 / 5389

页数：6

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