Emerging applications of exosomes in cancer therapeutics and diagnostics

被引：56

作者：

Inamdar, Sahil ^{[1
]}

Nitiyanandan, Rajeshwar ^{[2
]}

Rege, Kaushal ^{[1
]}

机构：

[1] Arizona State Univ, Chem Engn, 501 E Tyler Mall,ECG 303, Tempe, AZ 85287 USA

[2] Arizona State Univ, Biol Design Program, Tempe, AZ 85287 USA

来源：

BIOENGINEERING & TRANSLATIONAL MEDICINE | 2017年 / 2卷 / 01期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

CELL-DERIVED EXOSOMES; EXTRACELLULAR VESICLES; DRUG-DELIVERY; GENE-TRANSFER; CIRCULATING MICRORNA; MESSENGER-RNA; TUMOR; BIOMARKER; SERUM; MEMBRANE;

D O I：

10.1002/btm2.10059

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Exosomes are nanoscale extracellular vesicles that are shed from different cells in the body. Exosomes encapsulate several biomolecules including lipids, proteins, and nucleic acids, and can therefore play a key role in cellular communication. These vesicles can be isolated from different body fluids and their small sizes make them attractive in various biomedical applications. Here, we review state-of-the art approaches in exosome isolation and purification, and describe their potential use in cancer vaccines, drug delivery, and diagnostics.

引用

页码：70 / 80

页数：11

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