Improving the signal-to-noise ratio in gel permeation chromatography by Hadamard encoding

被引：9

作者：

Siegle, Alexander F. ^{[1
]}

Trapp, Oliver ^{[1
]}

机构：

[1] Heidelberg Univ, Inst Organ Chem, Neuenheimer Feld 270, D-69120 Heidelberg, Germany

来源：

JOURNAL OF CHROMATOGRAPHY A | 2016年 / 1448卷

基金：

欧洲研究理事会;

关键词：

Hadamard transform; Signal-to-noise ratio; Gel permeation chromatography; Multiplexing; TRANSFORM CAPILLARY-ELECTROPHORESIS; FLIGHT MASS-SPECTROMETRY; PERFORMANCE LIQUID-CHROMATOGRAPHY; ION MOBILITY SPECTROMETRY; GAS-CHROMATOGRAPHY; INJECTION; QUANTIFICATION; THROUGHPUT; ONLINE; BREATH;

D O I：

10.1016/j.chroma.2016.04.057

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Increasing sensitivity without further preconcentration steps is a major challenge in separation sciences. In this study a macro control approach that allows the implementation of Hadamard encoding on standard HPLC instrumentation was applied to the analysis of polysiloxane and polystyrene polymers by gel permeation chromatography. Here, the use of pseudo-random modulation sequences with 1023 elements (512 sample injections) improved the signal-to-noise ratio (S/N) by up to an order of magnitude. Comparison with conventional single injection confirmed the linearity and accuracy of the deconvolution process for the whole mass range of the column. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：93 / 97

页数：5

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