Naive CD4+T Cells Modified to Express a ROR1-Specific CAR Mediate Anti-Tumor Activity and Provide Superior Help to CD8+ROR1-CAR T Cells

被引：0
|
作者：
Hudecek, Michael [1 ]
Lupo-Stanghellini, Maria-Teresa [1 ]
Kosasih, Paula [1 ]
Bet, Jeannette [1 ]
Paszkiewicz, Paulina [1 ]
Maloney, David G. [1 ]
Jensen, Michael C. [2 ]
Rader, Christoph [3 ]
Riddell, Stanley R. [1 ]
机构：
[1] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
[2] Seattle Childrens Res Inst, Ctr Childhood Canc Res, Seattle, WA USA
[3] NCI, Expt Transplantat & Immunol Branch, Ctr Canc Res, Bethesda, MD 20892 USA
来源：
BLOOD | 2011年 / 118卷 / 21期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：294 / 294
页数：1
相关论文
共 50 条
  • [41] Naive tumor-specific CD4+T cells differentiated in vivo eradicate established melanoma
    Antony , Paul
    Xie, Ying
    Akpinarli, Akgul
    Maris, Charles
    Hipkiss, Edward
    Lane, Malcolm
    Kwon, Eun-Kyung
    Muranski, Pawel
    Restifo, Nicholas
    JOURNAL OF IMMUNOLOGY, 2010, 184
  • [42] In vivo trafficking of naive and activated anti-tumor transgenic CD8+ T-cells
    Matsui, K
    Allen, PM
    FASEB JOURNAL, 2001, 15 (04): : A661 - A661
  • [43] Neuroblastoma (NB), Medulloblastoma (MB), and Ewing's sarcoma (ES) express ROR1 and can be effectively targeted with NK cells modified to express an anti ROR1 chimeric antigen receptor (CAR)
    Elmacken, Mona
    Awasthi, Aradhana
    Ayello, Janet
    VanDeVen, Carmella
    Luo, Wen
    Liao, Yanling
    Riddell, Stanley
    Cairo, Mitchell S.
    CANCER RESEARCH, 2015, 75
  • [44] Tumor Immunology meets. Immunology: Modified cancer cells as professional APC for priming naive tumor-specific CD4+T cells
    Eddine, Farah Bou Nasser
    Ramia, Elise
    Tosi, Giovanna
    Forlani, Greta
    Accolla, Roberto S.
    ONCOIMMUNOLOGY, 2017, 6 (11):
  • [45] CAR-redirected natural killer T cells demonstrate superior antitumor activity to CAR-T cells through multimodal CD1d-dependent mechanisms
    Zhou, Xin
    Wang, Ying
    Dou, Zhangqi
    Delfanti, Gloria
    Tsahouridis, Ourania
    Pellegry, Caroline Marnata
    Zingarelli, Manuela
    Atassi, Gatphan
    Woodcock, Mark G.
    Casorati, Giulia
    Dellabona, Paolo
    Kim, William Y.
    Guo, Linjie
    Savoldo, Barbara
    Tsagaratou, Ageliki
    Milner, J. Justin
    Metelitsa, Leonid S.
    Dotti, Gianpietro
    NATURE CANCER, 2024, : 1607 - 1621
  • [46] Engineering Novel CD19/CD22 Dual-Target CAR-T Cells for Improved Anti-Tumor Activity
    Zeng, Wanying
    Zhang, Qing
    Zhu, Yangmin
    Ou, Ruiming
    Peng, Liang
    Wang, Baolei
    Shen, Huijuan
    Liu, Zhi
    Lu, Lisheng
    Zhang, Pumin
    Liu, Shuang
    CANCER INVESTIGATION, 2022, 40 (03) : 282 - 292
  • [47] Type 1 interferon licenses naive CD8 T cells to mediate anti-viral cytotoxicity
    Urban, Stina L.
    Berg, Leslie J.
    Welsh, Raymond M.
    VIROLOGY, 2016, 493 : 52 - 59
  • [48] In Vitro Priming of HIV-1-specific CD8+ T Cells from Naive T Cells
    Kuse, Nozomi
    Sun, Xiaoming
    Akahoshi, Tomohiro
    Lissina, Anna
    Appay, Victor
    Takiguchi, Masafumi
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2016, 32 : 171 - 171
  • [49] Polarized dendritic cells mediate CDS help for CD4+ T cells:: Helper function of CD8+ T cells in the development of Th1 responses
    Mailliard, RB
    Egawa, S
    Cai, Q
    Kalinska, A
    Lotze, MT
    Kapsenberg, ML
    Storkus, WJ
    Kalinski, P
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2001, 117 (04) : 1022 - 1022
  • [50] Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer
    Oh, David Y.
    Kwek, Serena S.
    Raju, Siddharth S.
    Li, Tony
    McCarthy, Elizabeth
    Chow, Eric
    Aran, Dvir
    Ilano, Arielle
    Pai, Chien-Chun Steven
    Rancan, Chiara
    Allaire, Kathryn
    Burra, Arun
    Sun, Yang
    Spitzer, Matthew H.
    Mangul, Serghei
    Porten, Sima
    Meng, Maxwell, V
    Friedlander, Terence W.
    Ye, Chun Jimmie
    Fong, Lawrence
    CELL, 2020, 181 (07) : 1612 - +
12345