Prevalence of persistent blood eosinophilia: relation to outcomes in patients with COPD

被引：118

作者：

Casanova, Ciro ^{[1
]}

Celli, Bartolome R. ^{[2
]}

de-Torres, Juan P. ^{[3
]}

Martinez-Gonzalez, Cristina ^{[4
]}

Cosio, Borja G. ^{[5
,6
]}

Pinto-Plata, Victor ^{[7
]}

de Lucas-Ramos, Pilar ^{[8
]}

Divo, Miguel ^{[2
]}

Fuster, Antonia ^{[9
]}

Peces-Barba, German ^{[6
,10
]}

Calle-Rubio, Myriam ^{[11
]}

Solanes, Ingrid ^{[12
]}

Aguero, Ramon ^{[13
]}

Feu-Collado, Nuria ^{[14
]}

Alfageme, Inmaculada ^{[15
]}

De Diego, Alfredo ^{[16
]}

Romero, Amparo ^{[17
]}

Balcells, Eva ^{[18
]}

Llunell, Antonia ^{[19
]}

Galdiz, Juan B. ^{[20
]}

Marin, Margarita ^{[21
]}

Moreno, Amalia ^{[22
]}

Cabrera, Carlos ^{[23
]}

Golpe, Rafael ^{[24
]}

Lacarcel, Celia ^{[25
]}

Soriano, Joan B. ^{[26
]}

Luis Lopez-Campos, Jose ^{[6
,27
]}

Soler-Cataluna, Juan J. ^{[28
]}

Marin, Jose M. ^{[29
]}

机构：

[1] Hosp Univ Ntra Sra La Candelaria, Pulmonol Dept, Tenerife, Spain

[2] Brigham & Womens Hosp, Pulm & Crit Care Dept, 75 Francis St, Boston, MA 02115 USA

[3] Clin Univ Navarra, Pulm Dept, Pamplona, Spain

[4] Hosp Cent Asturias, Pulm Dept, Oviedo, Spain

[5] Hosp Son Espases IdISPa, Pulm Dept, Palma de Mallorca, Spain

[6] Inst Salud Carlos III, CIBER Enfermedades Resp CIBERES, Madrid, Spain

[7] Baystate Med Ctr, Springfield, MA USA

[8] Hosp Gregorio Maranon, Pulm Dept 1, Madrid, Spain

[9] Hosp Son Llatzer, Pulm Dept, Mallorca, Spain

[10] Fdn Jimenez Diaz, Pulm Dept, Madrid, Spain

[11] Univ Complutense Madrid, Fac Med, Med Dept, Hosp Clin San Carlos,Pulm Dept, Madrid, Spain

[12] Univ Autonoma Barcelona, Hosp Santa Creu & Sant Pau, Pulm Dept, Barcelona, Spain

[13] Hosp Marques Valdecilla, Pulm Dept, Santander, Spain

[14] Hosp Univ Reina Sofia, IMIBIC, UCO, Pulm Dept, Cordoba, Spain

[15] Hosp Univ Valme, Pulm Dept, Seville, Spain

[16] Hosp Univ La Fe, Pulm Dept, Valencia, Spain

[17] Hosp Manacor, Pulm Dept, Mallorca, Spain

[18] Hosp Mar, Pulm Dept, Barcelona, Spain

[19] Hosp Tarrasa, Pulm Dept, Tarrasa, Spain

[20] Hosp Cruces, Pulm Dept, Bilbao, Spain

[21] Hosp Gen Castellon, Pulm Dept, Castellon de La Plana, Spain

[22] Hosp Parc Tauli, Pulm Dept, Barcelona, Spain

[23] Hosp Dr Negrin, Pulm Dept, Las Palmas Gran Canaria, Spain

[24] Hosp Univ Lucus Augusti, Pulm Dept, Lugo, Spain

[25] Hosp Ciudad Jaen, Pulm Dept, Jaen, Spain

[26] Hosp Univ La Princesa IISP, Inst Invest, Madrid, Spain

[27] Hosp Univ Virgen Rocio, Inst Biomed Sevilla IBiS, Unidad Med Quirrurg Enfermedades Resp, Seville, Spain

[28] Hosp Arnau Vilanova, Pulm Dept, Valencia, Spain

[29] Hosp Univ Miguel Servet, IISAragon, CIBERES, Pulm Dept, Zaragoza, Spain

来源：

EUROPEAN RESPIRATORY JOURNAL | 2017年 / 50卷 / 05期

关键词：

OBSTRUCTIVE PULMONARY-DISEASE; CLINICAL CHARACTERISTICS; INHALED CORTICOSTEROIDS; EXACERBATIONS; ASTHMA; FLUTICASONE; GUIDELINES; BIOMARKER; EFFICACY; DYSPNEA;

D O I：

10.1183/13993003.01162-2017

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The impact of blood eosinophilia in chronic obstructive pulmonary disease (COPD) remains controversial. To evaluate the prevalence and stability of a high level of blood eosinophils (>= 300 cells.mu L-1) and its relationship to outcomes, we determined blood eosinophils at baseline and over 2 years in 424 COPD patients (forced expiratory volume in 1 s (FEV1) 60% predicted) and 67 smokers without COPD from the CHAIN cohort, and in 308 COPD patients (FEV1 60% predicted) in the BODE cohort. We related eosinophil levels to exacerbations and survival using Cox hazard analysis. In COPD patients, 15.8% in the CHAIN cohort and 12.3% in the BODE cohort had persistently elevated blood eosinophils at all three visits. A significant proportion (43.8%) of patients had counts that oscillated above and below the cut-off points, while the rest had persistent eosinophil levels <300 cells.mu L-1. A similar eosinophil blood pattern was observed in controls. Exacerbation rates did not differ in patients with and without eosinophilia. All-cause mortality was lower in patients with high eosinophils compared with those with values <300 cells.mu L-1 (15.8% versus 33.7%; p=0.026). In patients with COPD, blood eosinophils >= 300 cells.mu L-1 persisting over 2 years was not a risk factor for COPD exacerbations. High eosinophil count was associated with better survival.

引用

页数：11

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