Concepts of advanced therapeutic delivery systems for the management of remodeling and inflammation in airway diseases

被引：11
|
作者：
Dhanjal, Daljeet Singh [1 ]
Sharma, Parvarish [2 ]
Mehta, Meenu [3 ]
Tambuwala, Murtaza M. [4 ]
Prasher, Parteek [5 ]
Paudel, Keshav R. [6 ,7 ]
Liu, Gang [6 ,7 ]
Shukla, Shakti D.
Hansbro, Philip M. [6 ,7 ]
Chellappan, Dinesh Kumar [8 ]
Dua, Kamal [3 ]
Satija, Saurabh [2 ]
机构：
[1] Lovely Profess Univ, Sch Bioengn & Biosci, Phagwara 144411, Punjab, India
[2] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144411, Punjab, India
[3] Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Sydney, NSW 2007, Australia
[4] Ulster Univ, Sch Pharm & Pharmaceut Sci, Coleraine BT52 1SA, Londonderry, North Ireland
[5] Univ Petr & Energy Studies, Dept Chem, Dehra Dun 248007, Uttarakhand, India
[6] Centenary Inst, Ctr Inflammat, Sydney, NSW, Australia
[7] Univ Technol Sydney, Sch Life Sci, Fac Sci, Sydney, NSW, Australia
[8] Int Med Univ, Sch Pharm, Dept Life Sci, Kuala Lumpur 57000, Malaysia
来源：
FUTURE MEDICINAL CHEMISTRY | 2022年 / 14卷 / 04期
基金：
英国医学研究理事会;
关键词：
COPD; NDDS; remodeling; respiratory disorders; OBSTRUCTIVE PULMONARY-DISEASE; OVERCOMING BIOLOGICAL BARRIERS; SOLID LIPID NANOPARTICLES; DRUG-DELIVERY; INHALER TECHNIQUE; CARBON NANOTUBES; MURINE MODEL; IN-VITRO; ASTHMA; CHALLENGES;
D O I：
10.4155/fmc-2021-0081
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Chronic respiratory disorders (CRDs) affect millions of people worldwide. Pathophysiological changes to the normal airway wall structure, including changes in the composition and organization of its cellular and molecular constituents, are referred to as airway remodeling. The inadequacy of effective treatment strategies and scarcity of novel therapies available for the treatment and management of chronic respiratory diseases have given rise to a serious impediment in the clinical management of such diseases. The progress made in advanced drug delivery, has offered additional advantages to fight against the emerging complications of airway remodeling. This review aims to address the gaps in current knowledge about airway remodeling, the relationships between remodeling, inflammation, clinical phenotypes and the significance of using novel drug delivery methods.
引用
收藏
页码：271 / 288
页数：18
相关论文
共 50 条
  • [31] Biomimetic drug-delivery systems for the management of brain diseases
    Chen, Yao-xing
    Wei, Chen-xuan
    Lyu, Ying-qi
    Chen, Hong-zhuan
    Jiang, Gan
    Gao, Xiao-ling
    [J]. BIOMATERIALS SCIENCE, 2020, 8 (04) : 1073 - 1088
  • [32] Advanced and controlled drug delivery systems in clinical disease management
    Brouwers, JRBJ
    [J]. PHARMACY WORLD & SCIENCE, 1996, 18 (05): : 153 - 162
  • [33] Pulmonary Hypertension in Autoimmune Diseases - A Review of New Concepts in Screening, Diagnosis and Therapeutic Management
    Anghel, Daniela
    Nicolau, Iulia N.
    Mihalca, Liana I.
    Petrache, Oana G.
    Costache, Raluca S.
    Opris-Belinski, Daniela
    Bojinca, Violeta C.
    Radu, Florentina Ionita
    [J]. ROMANIAN JOURNAL OF MILITARY MEDICINE, 2023, 126 (04) : 433 - 441
  • [34] Recent trends in the transdermal delivery of therapeutic agents used for the management of neurodegenerative diseases
    Ita, Kevin
    [J]. JOURNAL OF DRUG TARGETING, 2017, 25 (05) : 406 - 419
  • [35] MANAGEMENT OF AIRWAY REMODELING IN A MOUSE MODEL OF ALLERGIC AIRWAY INFLAMMATION ASSOCIATING HUMAN DENTAL PULP STEM CELLS AND MODERATE AEROBIC TRAINING
    Fragoso, F. Y. I.
    Michelotto, P. V., Jr.
    Mariani, L. P. R. S.
    Leite, L. M. B.
    Brofman, P. R. S.
    [J]. CYTOTHERAPY, 2021, 23 (04) : 22 - 22
  • [36] Advanced drug-delivery approaches in managing P53-mediated lung diseases remodeling
    Bhat, Asif Ahmad
    Gilhotra, Ritu
    Singh, Yogendra
    Sharma, Sanjay
    Pinto, Terezinha de Jesus Andreoli
    Ferraz, Humberto Gomes
    Singh, Sachin Kumar
    Dua, Kamal
    Gupta, Gaurav
    [J]. NANOMEDICINE, 2023, 18 (07) : 583 - 587
  • [37] Advanced drug delivery systems targeting NF-κB in respiratory diseases
    Prasher, Parteek
    Sharma, Mousmee
    Chellappan, Dinesh Kumar
    Gupta, Gaurav
    Jha, Niraj Kumar
    Singh, Sachin Kumar
    MacLoughlin, Ronan
    Pinto, Terezinha J.
    Lobenberg, Raimar
    Dua, Kamal
    [J]. FUTURE MEDICINAL CHEMISTRY, 2021, 13 (13) : 1087 - 1090
  • [38] Targeting mucus barrier in respiratory diseases by chemically modified advanced delivery systems
    Prasher, Parteek
    Sharma, Mousmee
    Singh, Sachin Kumar
    Gulati, Monica
    Jha, Niraj Kumar
    Gupta, Piyush Kumar
    Gupta, Gaurav
    Chellappan, Dinesh Kumar
    Zacconi, Flavia
    Pinto, Terezinha de Jesus Andreoli
    Chan, Yinghan
    Liu, Gang
    Paudel, Keshav Raj
    Hansbro, Philip M.
    Oliver, Brian Gregory George
    Dua, Kamal
    [J]. CHEMICO-BIOLOGICAL INTERACTIONS, 2022, 365
  • [39] Therapeutic potential of microneedles based delivery systems for the management of atopic dermatitis
    Shukla, Shalini
    Mamale, Kalpana Balu
    Arya, Rajeshwar K. K.
    Kaundal, Ravinder K.
    Shukla, Rahul
    [J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2023, 84
  • [40] INDUSTRIAL MANAGEMENT IN ADVANCED PRODUCTION SYSTEMS - SOME THEORETICAL CONCEPTS AND PRELIMINARY FINDINGS
    BURACK, EH
    [J]. ADMINISTRATIVE SCIENCE QUARTERLY, 1967, 12 (03) : 479 - 500
12345