Survival analysis with quantile regression models

被引:226
|
作者
Peng, Limin [1 ]
Huang, Yijian [1 ]
机构
[1] Emory Univ, Dept Biostat, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
censoring; empirical process; martingale; regression quantile; resampling; varying-effects model;
D O I
10.1198/016214508000000355
中图分类号
O21 [概率论与数理统计]; C8 [统计学];
学科分类号
020208 ; 070103 ; 0714 ;
摘要
Quantile regression offers great flexibility in assessing covariate effects on event times, thereby attracting considerable interests in its applications in survival analysis. But currently available methods often require stringent assumptions or complex algorithms. In this article we develop a new quantile regression approach for survival data subject to conditionally independent censoring. The proposed martingale-based estimating equations naturally lead to a simple algorithm that involves minimizations only of L-1-type convex functions. We establish uniform consistency and weak convergence of the resultant estimators. We develop inferences accordingly, including hypothesis testing, second-stage inference, and model diagnostics. We evaluate the finite-sample performance of the proposed methods through extensive simulation studies. An analysis of a recent dialysis study illustrates the practical utility of our proposals.
引用
收藏
页码:637 / 649
页数:13
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