Allosteric uncoupling of microtubule depolymerase activity from motility in human Kinesin-5

被引：0
|
作者：
Downs, Micquel [1 ]
Kim, Catherine [1 ]
Kim, Elizabeth [1 ]
Liu, Liqiong [1 ]
Parameswaran, Sreeja [1 ]
Kim, Sunyoung [1 ]
Wojcik, Edward [1 ]
机构：
[1] Louisiana State Univ Hlth Sci Ctr New Orleans, New Orleans, LA USA
来源：
FASEB JOURNAL | 2020年 / 34卷
关键词：
D O I：
10.1096/fasebj.2020.34.s1.09434
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页数：2
相关论文
共 50 条
  • [41] A Nonmotor Microtubule Binding Site in Kinesin-5 Is Required for Filament Crosslinking and Sliding
    Weinger, Joshua S.
    Qiu, Minhua
    Yang, Ge
    Kapoor, Tarun M.
    CURRENT BIOLOGY, 2011, 21 (02) : 154 - 160
  • [42] Kinesin-5 Acts as a Microtubule Stabilizer, Polymerase and Plus-Tip Tracker
    Chen, Yalei
    Hancock, William O.
    BIOPHYSICAL JOURNAL, 2015, 108 (02) : 21A - 21A
  • [43] Effect of Kinesin-5 Tail Domain on Motor Dynamics for Antiparallel Microtubule Sliding
    Liu, Yuying
    Wang, Yao
    Wang, Pengye
    Xie, Ping
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (15)
  • [44] The Effect of Monastrol on the Processive Motility of a Dimeric Kinesin-5 Head/Kinesin-1 Stalk Chimera
    Lakaemper, Stefan
    Thiede, Christina
    Dueselder, Andre
    Reiter, Stefanie
    Korneev, Mikhail J.
    Kapitein, Lukas C.
    Peterman, Erwin J. G.
    Schmidt, Christoph F.
    JOURNAL OF MOLECULAR BIOLOGY, 2010, 399 (01) : 1 - 8
  • [45] Molecular mechanism of the bidirectional motility of yeast kinesin-5/Cin8
    Qiu, Weihong
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 250
  • [46] Using a comprehensive approach to investigate the interaction between Kinesin-5/Eg5 and the microtubule
    Guo, Wenhan
    Sun, Shengjie
    Sanchez, Jason E.
    Lopez-Hernandez, Alan E.
    Ale, Tolulope A.
    Chen, Jiawei
    Afrin, Tanjina
    Qiu, Weihong
    Xie, Yixin
    Li, Lin
    COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2022, 20 : 4305 - 4314
  • [47] The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression
    Mayr, Monika I.
    Huemmer, Stefan
    Bormann, Jenny
    Gruener, Tamara
    Adio, Sarah
    Woehlke, Guenther
    Mayer, Thomas U.
    CURRENT BIOLOGY, 2007, 17 (06) : 488 - 498
  • [48] Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy
    Pena, Alejandro
    Sweeney, Aaron
    Cook, Alexander D.
    Topf, Maya
    Moores, Carolyn A.
    STRUCTURE, 2020, 28 (04) : 450 - +
  • [49] Polyphenol MHQP as an allosteric inhibitor of Kinesin-5: Cease the molecular catwalk of "Drunken Sailor"
    Shukla, Manjari
    Maji, Sushobhan
    Rajarshi, Keshav
    Bhattacharyya, Sudipta
    INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS, 2023, 60 (09): : 703 - 709
  • [50] The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression
    Mayr, M.
    Huemmer, S.
    Bormann, J.
    Mayer, T.
    FEBS JOURNAL, 2007, 274 : 294 - 294
12345