Time to Akt: Superior tumor-reactive T cells for adoptive immunotherapy

被引：3
|
作者：
van der Waart, Anniek B. [1 ]
Hobo, Willemijn [1 ]
Dolstra, Harry [1 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Dept Lab Med, Hematol Lab, NL-6525 ED Nijmegen, Netherlands
来源：
ONCOIMMUNOLOGY | 2015年 / 4卷 / 05期
关键词：
adoptive T cell therapy; Akt; dendritic cell; IL-7; IL-15; stem cell transplantation; T-cell differentiation; Wnt; CANCER-THERAPY; GENERATION; INHIBITION;
D O I：
10.1080/2162402X.2014.1003016
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
T cells are crucial players in the protection against cancer, and can be used in adoptive cell therapy to prevent or treat relapse. However, their state of differentiation determines their effectiveness, with early memory cells being the most favorable. Here, we discuss restraining of differentiation to engineer the ultimate tumor-reactive T cell.
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页数：3
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