Biocatalytic synthesis of quinoline derivatives via α-amylase catalysed one-pot domino aza-Michael/Aldol/aromatization reactions

被引：6

作者：

Dutt, Sunil ^{[1
]}

Tyagi, Vikas ^{[1
]}

机构：

[1] Thapar Inst Engn & Technol, Sch Chem & Biochem, Patiala 147004, Punjab, India

来源：

TETRAHEDRON LETTERS | 2021年 / 87卷

关键词：

Biocatalyst; alpha-Amylase; Cascade reactions; Aza-Michael; Aldol reaction; MICHAEL/ALDOL REACTION; ENANTIOSELECTIVE SYNTHESIS; FRIEDLANDER SYNTHESIS; CASCADE REACTIONS; CONSTRUCTION; HYDROLASES;

D O I：

10.1016/j.tetlet.2021.153527

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Quinoline moiety is a part of various drug molecules and natural products. Previously, a number of catalysts have been made available to synthesize substituted quinolines. Herein, we are reporting alpha-amylase catalysed synthesis of substituted quinolines via one-pot domino aza-Michael/Aldol/aromatization reactions. Moreover, the alpha-amylase enzyme from Aspergillus oryzae was found to catalyse the cascade reaction of various 2-aminobenzaldehydes with alpha, beta-unsaturated carbonyls in high catalytic efficiency (56-86% yield). (C) 2021 Elsevier Ltd. All rights reserved.

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页数：6

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