Cultures of equine respiratory epithelial cells and organ explants as tools for the study of equine influenza virus infection

被引：17

作者：

Lin, C ^{[1
]}

Holland, RE ^{[1
]}

Williams, NM ^{[1
]}

Chambers, TM ^{[1
]}

机构：

[1] Univ Kentucky, Dept Vet Sci, Maxwell H Gluck Equine Res Ctr 108, Lexington, KY 40546 USA

来源：

ARCHIVES OF VIROLOGY | 2001年 / 146卷 / 11期

关键词：

D O I：

10.1007/s007050170034

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Equine nasal turbinate epithelial cells and tracheal rafts were maintained with sustained viability in culture. Both types of culture supported productive replication of equine influenza virus (equine-2, subtype H3N8) and cell death occurred through apoptosis following viral infection. Thus, primary respiratory epithelial cell and organ cultures of equine origin may be valuable as alternatives to the intact animal for studying the virus-host interaction of equine respiratory viruses including influenza.

引用

页码：2239 / 2247

页数：9

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