Pellasoren: Structure Elucidation, Biosynthesis, and Total Synthesis of a Cytotoxic Secondary Metabolite from Sorangium cellulosum

被引:52
|
作者
Jahns, Christine [1 ,2 ]
Hoffmann, Thomas [3 ]
Mueller, Stefan [3 ]
Gerth, Klaus [2 ]
Washausen, Peter [2 ]
Hoefle, Gerhard [2 ]
Reichenbach, Hans [2 ]
Kalesse, Markus [1 ,2 ]
Mueller, Rolf [3 ]
机构
[1] Leibniz Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany
[2] HZI, Braunschweig, Germany
[3] Univ Saarland, Helmholtz Zentrum Infekt Forsch & Pharmazeut Biot, HIPS, D-66123 Saarbrucken, Germany
关键词
biosynthesis; myxobacteria; natural products; Sorangium cellulosum; total synthesis; MODULAR POLYKETIDE SYNTHASES; ANSAMITOCIN; PREDICTION; SUBSTRATE; GENES; ALDOL; UNITS;
D O I
10.1002/anie.201200327
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:5239 / 5243
页数:5
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