[Ru(bpy)2(5-cyanouracil)2]2+ as a Potential Light-Activated Dual-Action Therapeutic Agent

被引：142
|
作者：
Garner, Robert N. [2 ]
Gallucci, Judith C. [2 ]
Dunbar, Kim R. [1 ]
Turro, Claudia [2 ]
机构：
[1] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA
[2] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA
来源：
INORGANIC CHEMISTRY | 2011年 / 50卷 / 19期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
PHOTOPHYSICAL PROPERTIES; RUTHENIUM(II) COMPLEXES; DNA PHOTOCLEAVAGE; LIGAND-EXCHANGE; CYTOTOXICITY; PHOTOCYTOTOXICITY; PHOTOSUBSTITUTION; PHOTOCHEMISTRY; BINDING; SERIES;
D O I：
10.1021/ic201615u
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The cation cis-[Ru(bpy)(2)(SCNU)(2)](2+) (bpy = 2,2'-bipyridine; SCNU = S-cyanouracil) was synthesized and investigated for use as a potential light-activated dual-action therapeutic agent. The complex undergoes efficient photoinduced SCNU ligand exchange for solvent water molecules, thus simultaneously releasing biologically active SCNU and generating [Ru(bpy)(2)(H2O)(2)](2+). The latter binds covalently to ds-DNA, such that photolysis results in the generation of 3 equiv of potential therapeutic agents from a single molecule.
引用
收藏
页码：9213 / 9215
页数：3
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