Cytotoxic oxasqualenoids from the red alga Laurencia viridis

被引：42

作者：

Cen-Pacheco, Francisco ^{[1
]}

Villa-Pulgarin, Janny A. ^{[2
,3
]}

Mollinedo, Faustino ^{[2
]}

Norte, Manuel ^{[1
]}

Daranas, Antonio H. ^{[1
]}

Fernandez, Jose J. ^{[1
]}

机构：

[1] Univ la Laguna, Inst Univ Bioorgan Antonio Gonzalez, Tenerife 38206, Spain

[2] Univ Salamanca, CSIC, Ctr Invest Canc, Inst Biol Mol & Celular Canc, E-37007 Salamanca, Spain

[3] Univ Salamanca, Ctr Hispano Luso Invest Agr CIALE, APOINTECH, E-37185 Salamanca, Spain

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 46卷 / 08期

关键词：

Oxasqualenoids; Marine polyether; Laurencia; Integrin inhibitor; COUPLING-CONSTANTS; APOPTOSIS; ANTAGONISTS; TARGETS;

D O I：

10.1016/j.ejmech.2011.04.051

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new polyether squalene derivatives 15-dehydroxythyrsenol A (2), prethyrsenol A (3) and 13-hydroxyprethyrsenol A (4) have been isolated from the red alga Laurencia viridis. Their structures were determined through the interpretation of NMR spectroscopic data and chemical correlations. In addition, four semi-synthetic compounds modulating the solubility of the lead compound dehydrothyrsiferol (1) were prepared without loss of activity. The cytotoxicity of the new compounds exhibited low mu M activities. In order to explain their biological properties, docking simulations of the natural and synthetic compounds onto the alpha v beta 3 integrin binding region were carried out. (C) 2011 Elsevier Masson SAS. All rights reserved.

引用

页码：3302 / 3308

页数：7

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