Radiofrequency ablation is effective for the treatment of high-grade dysplasia in Barrett's esophagus after failed photodynamic therapy

被引：15

作者：

Dunn, J. M. ^{[1
]}

Banks, M. R. ^{[3
]}

Oukrif, D. ^{[2
]}

Mackenzie, G. D. ^{[1
]}

Thorpe, S. ^{[1
]}

Rodriguez-Justo, M. ^{[2
]}

Winstanley, A. ^{[2
]}

Bown, S. G. ^{[1
]}

Novelli, M. R. ^{[2
]}

Lovat, L. B. ^{[1
,3
]}

机构：

[1] UCL, Natl Med Laser Ctr, Dept Surg, London W1W 7EJ, England

[2] UCL, Dept Histopathol, London W1W 7EJ, England

[3] Univ Coll London Hosp NHS Fdn Trust, Dept Gastroenterol, London, England

来源：

ENDOSCOPY | 2011年 / 43卷 / 07期

关键词：

FOCAL ABLATION; SAFETY;

D O I：

10.1055/s-0030-1256443

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Endoscopic radiofrequency ablation (RFA) is an effective treatment for high-grade dysplasia in Barrett's esophagus in ablation-nave patients, but no studies have evaluated its use in patients in whom ablative therapy has previously failed. We describe 14 patients with residual high-grade dysplasia following aminolevulinic acid or Photofrin (porfimer sodium) photodynamic therapy (PDT). An overall complete reversal of dysplasia was achieved in 86% with a combination of RFA and rescue endoscopic mucosal resection. The median total follow-up is 19 months. The rate of strictures was 7% (1/14) and there was a low rate of buried glands (0.5% follow-up biopsies). These data suggest RFA is both safe and effective for eradication of high-grade dysplasia in patients in whom PDT has failed.

引用

页码：627 / 630

页数：4

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