Circulating FGF-21 levels in normal subjects and in newly diagnose patients with type 2 diabetes Mellitus

被引：196
|
作者：
Chen, W. -W. [1 ]
Li, L. [2 ,3 ]
Yang, G. -Y. [1 ]
Li, K. [1 ]
Qi, X. -Y. [1 ]
Zhu, W. [1 ]
Tang, Y. [4 ]
Liu, H. [5 ]
Boden, G. [6 ,7 ]
机构：
[1] Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Chongqing 400010, Peoples R China
[2] Chongqing Med Univ, Minist Educ, Dept Clin Biochem, Chongqing, Peoples R China
[3] Chongqing Med Univ, Minist Educ, Key Lab Lab Med Diagnost, Chongqing, Peoples R China
[4] Centocor Inc, Oncol Res, Malvern, PA 19355 USA
[5] Univ Mississippi, Med Ctr, Dept Pediat, Jackson, MS 39216 USA
[6] Temple Univ, Sch Med, Div Endocrinol Diabet Metab, Philadelphia, PA 19122 USA
[7] Temple Univ, Sch Med, Clin Res Ctr, Philadelphia, PA 19122 USA
来源：
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES | 2008年 / 116卷 / 01期
关键词：
FGF-21; insulin resistance; T2DM;
D O I：
10.1055/s-2007-985148
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Fibroplast growth factor (FGF-21) is a recently discovered metabolic regulator. Its pathophysiologic role in humans remains unknown. In this study, we have investigated whether or not plasma FGF-21 level was different in patients with type 2 diabetes mellitus (T2DM) and nondiabetic controls. We also assessed associations between plasma FGF-21 body composition and several metabolic parameters. Fasting FGF-21 levels were significantly increased in patients with T2DM compared with controls (1.82 +/- 0.65 vs. 1.53 +/- 0.60 mu g/L, P<0.05). In T2DM patients, fasting plasma FGF-21 correlate negatively with fasting blood glucose (r = -0.31, P< 0.05). Multiple regression analysis showed that FBG, plasma insulin and HOMA(IS) were independent influencing plasma FGF-21 levels. The present work suggests a potential role for FGF-21 in the pathogenesis of insulin resistance and T2DM.
引用
收藏
页码：65 / 68
页数：4
相关论文
共 50 条
  • [21] Association of Circulating TXNIP Levels with Fatty Liver in Newly Diagnosed Type 2 Diabetes Mellitus
    Guo, Yuting
    Chen, Juan
    Liu, Nan
    Liu, Zheng
    Shi, Bimin
    Sun, Hong
    DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY, 2022, 15 : 225 - 233
  • [22] Circulating zonulin levels in newly diagnosed Chinese type 2 diabetes patients
    Zhang, D.
    Zhang, L.
    Zheng, Y.
    Yue, F.
    Russell, R. D.
    Zeng, Y.
    DIABETES RESEARCH AND CLINICAL PRACTICE, 2014, 106 (02) : 312 - 318
  • [23] Resistance training attenuates circulating FGF-21 and myostatin and improves insulin resistance in elderly men with and without type 2 diabetes mellitus: A randomised controlled clinical trial
    Shabkhiz, Fatemeh
    Khalafi, Mousa
    Rosenkranz, Sara
    Karimi, Pouran
    Moghadami, Kamilia
    EUROPEAN JOURNAL OF SPORT SCIENCE, 2021, 21 (04) : 636 - 645
  • [24] Fibroblast Growth Factor-21 (FGF-21) predicts development of diabetes and pioglitazone attenuates the increase in FGF-21 in subjects with IGT: results from the ACTNOW study
    Tripathy, D.
    Alonzo, R. P.
    Chavez-Velazquez, A.
    Martinez, R.
    Musi, N.
    Defronzo, R.
    DIABETOLOGIA, 2016, 59 : S164 - S164
  • [25] Serum levels of proamylin and amylin in normal subjects and patients with impaired glucose regulation and type 2 diabetes mellitus
    Zheng, Xiaoya
    Ren, Wei
    Zhang, Suhua
    Liu, Jingjing
    Li, Sufang
    Li, Jinchao
    Yang, Ping
    He, Jun
    Su, Shaochu
    Li, Ping
    ACTA DIABETOLOGICA, 2010, 47 (03) : 265 - 270
  • [26] Serum levels of proamylin and amylin in normal subjects and patients with impaired glucose regulation and type 2 diabetes mellitus
    Xiaoya Zheng
    Wei Ren
    Suhua Zhang
    Jingjing Liu
    Sufang Li
    Jinchao Li
    Ping Yang
    Jun He
    Shaochu Su
    Ping Li
    Acta Diabetologica, 2010, 47 : 265 - 270
  • [27] Baseline Circulating FGF-21 Levels and Increase after Fenofibrate Treatment Predict More Rapid Glycemic Progression in Type 2 Diabetes: Results from the FIELD Study
    Ong, Kwok Leung
    O'Connell, Rachel
    Januszewski, Andrzej S.
    Jenkins, Alicia J.
    Xu, Aimin
    Sullivan, David R.
    Barter, Philip J.
    Scott, Russell S.
    Taskinen, Marja Riitta
    Waldman, Boris
    Colman, Peter G.
    Best, James D.
    Simes, John R.
    Rye, Kerry Anne
    Keech, Anthony C.
    DIABETES, 2017, 66 : A458 - A458
  • [28] Circulating obestatin levels in normal and Type 2 diabetic subjects
    D. H. St-Pierre
    F. Settanni
    I. Olivetti
    E. Gramaglia
    M. Tomelini
    R. Granata
    F. Prodam
    A. Benso
    E. Ghigo
    F. Broglio
    Journal of Endocrinological Investigation, 2010, 33 : 211 - 214
  • [29] Circulating obestatin levels in normal and Type 2 diabetic subjects
    St-Pierre, D. H.
    Settanni, F.
    Olivetti, I.
    Gramaglia, E.
    Tomelini, M.
    Granata, R.
    Prodam, F.
    Benso, A.
    Ghigo, E.
    Broglio, F.
    JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2010, 33 (04) : 211 - 214
  • [30] Elevated plasma levels of SPARC in patients with newly diagnosed type 2 diabetes mellitus
    Zhang, Y.
    Li, L.
    Yang, G.
    DIABETOLOGIA, 2011, 54 : S254 - S254
12345