Multi-modal combination gene therapy for malignant glioma using replication-defective HSV vectors

被引：9
|
作者：
Burton, EA [1 ]
Glorioso, JC [1 ]
机构：
[1] Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA
来源：
DRUG DISCOVERY TODAY | 2001年 / 6卷 / 07期
关键词：
D O I：
10.1016/S1359-6446(01)01713-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Herpes simplex virus (HSV) may be modified to produce a nonpathogenic vector that is capable of delivering multiple transgenes simultaneously to cells, both safely and efficiently. We have exploited this property to develop viruses that target glioblastoma, a malignancy that is currently associated with a poor prognosis. Using rationally selected combinations of therapeutic transgenes coupled with gamma-knife radiotherapy, the ablation of experimental tumours in animal models has been demonstrated. Combination gene therapy using replication-defective HSV vectors represents a promising and exciting approach to tackling malignancy in the CNS.
引用
收藏
页码：347 / 356
页数：10
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