Effect of lncRNA H19 on nerve degeneration and regeneration after sciatic nerve injury in rats

被引：7
|
作者：
Li, Yuting [1 ,2 ]
Cai, Min [1 ,2 ,3 ]
Feng, Yumei [1 ,2 ]
Yung, Bryant [1 ,2 ]
Wang, Yi [1 ,2 ]
Gao, Nannan [1 ,2 ]
Xu, Xi [4 ]
Zhang, Huanhuan [1 ,2 ]
Huang, Huiwei [3 ]
Yao, Dengbing [1 ,2 ]
机构：
[1] Nantong Univ, Sch Life Sci, Coinnovat Ctr Neuroregenerat, Key Lab Neuroregenerat Jiangsu, Nantong 226019, Jiangsu, Peoples R China
[2] Nantong Univ, Minist Educ, Coinnovat Ctr Neuroregenerat, Nantong 226019, Jiangsu, Peoples R China
[3] Nantong Univ, Diagnost Lab, Sch Med, Nantong, Peoples R China
[4] Nantong Univ, Rehabil Med Ctr, Affiliated Hosp, Nantong, Peoples R China
来源：
DEVELOPMENTAL NEUROBIOLOGY | 2022年 / 82卷 / 01期
基金：
中国国家自然科学基金;
关键词：
H19; long noncoding RNA (lncRNA); peripheral nerve regeneration; rat; sciatic nerve injury; Wallerian degeneration (WD); LONG NONCODING RNAS; SCHWANN-CELL PROLIFERATION; WALLERIAN DEGENERATION; INFLAMMATORY RESPONSE; DIFFERENTIATION; METHYLATION; MECHANISMS; MAINTAINS; APOPTOSIS; DISEASE;
D O I：
10.1002/dneu.22861
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Hundreds of millions of people worldwide suffer from peripheral nerve damage resulting from car accidents, falls, industrial accidents, residential accidents, and wars. The purpose of our study was to further investigate the effects of Wallerian degeneration (WD) after rat sciatic nerve injury and to screen for critical long noncoding RNAs (lncRNAs) in WD. We found H19 to be essential for nerve degeneration and regeneration and to be highly expressed in the sciatic nerves of rats with WD. lncRNA H19 potentially impaired the recovery of sciatic nerve function in rats. H19 was mainly localized in the cytoplasm of Schwann cells (SCs) and promoted their migration. H19 promoted the apoptosis of dorsal root ganglion (DRG) neurons and slowed the growth of DRG axons. The lncRNA H19 may play a role in WD through the Wnt/beta-catenin signaling pathway and is coexpressed with a variety of crucial mRNAs during WD. These data provide further insight into the molecular mechanisms of WD.
引用
收藏
页码：98 / 111
页数：14
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