Synthesis of Nitriles from Primary Amides or Aldoximes under Conditions of a Catalytic Swern Oxidation

被引：72

作者：

Ding, Rui ^{[1
]}

Liu, Yongguo ^{[1
]}

Han, Mengru ^{[1
]}

Jiao, Wenyi ^{[1
]}

Li, Jiaqi ^{[1
]}

Tian, Hongyu ^{[1
]}

Sun, Baoguo ^{[1
]}

机构：

[1] Beijing Technol & Business Univ, Beijing Key Lab Flavor Chem, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100048, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 20期

关键词：

OXALYL CHLORIDE; BOND-CLEAVAGE; CONVERSION; DEHYDRATION; OXIMES; ACIDS; HETEROCYCLES; DERIVATIVES; GENERATION; ALKYNES;

D O I：

10.1021/acs.joc.8b02190

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of nitriles from primary amides or aldoximes was achieved by using oxalyl chloride with a catalytic amount of dimethyl sulfoxide in the presence of Et3N. The reactions were complete within 1 h after addition at room temperature. A diverse range of cyano compounds were obtained in good to excellent yields, including aromatic, heteroaromatic, cyclic, and acyclic aliphatic species.

引用

页码：12939 / 12944

页数：6

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