Androgen insensitivity syndrome after preimplantation genetic diagnosis for sex selection: A case report

Objective: To report the first case of androgen insensitivity syndrome after preimplantation genetic diagnosis (PGD) for sex selection. Design: Case report. Setting: The Farah Hospital (a private tertiary referral fertility center). Patient(s): A healthy woman with three daughters underwent PGD for sex selection, seeking a male baby. Intervention(s): PGD was done and the woman became pregnant. Ultrasound examination showed female phenotype. Amniocentesis was performed and culture of cells confirmed XY karyotype. Result(s): Karyotyping confirmed the diagnosis of XY genotype and pregnancy was terminated. Conclusion(s): Although androgen insensitivity syndrome is very rare, it can occur in cases of PGD for sex selection. (Fertil Steril (R) 2009;92:1169.e5-e7. (C)2009 by American Society for Reproductive Medicine.)