Integrated multi-sensor system for parallel in-situ monitoring of cell nutrients, metabolites and cell mass in biotechnological processes

被引：12

作者：

Mross, Stefan ^{[1
]}

Zimmermann, Tom ^{[1
]}

Winkin, Nadine ^{[2
]}

Kraft, Michael ^{[3
]}

Vogt, Holger ^{[1
]}

机构：

[1] Fraunhofer Inst Microelect Circuits & Syst, Duisburg, Germany

[2] Rhein Westfal TH Aachen, Inst Mat Elect Engn, Chair 1, Aachen, Germany

[3] Univ Liege, Dept Elect Engn & Comp Sci, Montefiore Inst, B-4000 Liege, Belgium

来源：

EUROSENSORS 2015 | 2015年 / 120卷

关键词：

Bioprocess monitoring; multi-sensor system; in-situ monitoring; enzymatic sensors; cell mass sensor;

D O I：

10.1016/j.proeng.2015.08.642

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

We report on a multi-sensor system for the parallel in-situ monitoring of cell nutrients, metabolites and cell mass in biotechnological processes. The integration of enzyme sensors and impedance spectroscopy on one chip for applications in bioreactors is demonstrated for the first time to our best knowledge. Measurements of glucose and lactate concentrations in a wide range are shown with linear ranges up to 600 mM and 900 mM, respectively. The glucose and cell mass sensor in parallel are successfully employed in a cell culture of Saccharomyces cerevisiae to monitor glucose consumption and increasing mass of the cells. (C) 2015 The Authors. Published by Elsevier Ltd.

引用

页码：372 / 375

页数：4

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