Chemiluminescence from the biomimetic reaction of 1,2,4-trioxolanes and 1,2,4,5-tetroxanes with ferrous ions

被引：15

作者：

Kazakov, D. V. ^{[1
]}

Timerbaev, A. R. ^{[1
]}

Safarov, F. E. ^{[1
]}

Nazirov, T. I. ^{[1
]}

Kazakova, O. B. ^{[1
]}

Ishmuratov, G. Y. ^{[1
]}

Terent'ev, A. O. ^{[2
]}

Borisov, D. A. ^{[2
]}

Tolstikov, A. G. ^{[3
]}

Tolstikov, G. A. ^{[1
]}

Adam, W. ^{[4
,5
]}

机构：

[1] RAS, Ufa Sci Ctr, Inst Organ Chem, Ufa 450054, Russia

[2] RAS, Zelinsky Inst Organ Chem, Moscow 119991, Russia

[3] RAS, Inst Petrochem & Catalysis, Ufa 450075, Russia

[4] Univ Puerto Rico, Dept Chem, Rio Piedras, PR 00931 USA

[5] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

来源：

RSC ADVANCES | 2012年 / 2卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

DRUG-DEVELOPMENT CANDIDATE; OXYGEN O-2 ((1)DELTA(G)); ANTIMALARIAL PEROXIDES; SYNTHETIC DERIVATIVES; ACID; ARTEMISININ; HEME; BIOLUMINESCENCE; IDENTIFICATION; OXIDATION;

D O I：

10.1039/c1ra00784j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The 1,2,4-trioxolane and 1,2,4,5-tetroxane pharmacophores are currently considered as the next generation of synthetic antimalarial drugs. This fact has stimulated the exploration of the chemiluminescence displayed by these cyclic peroxides in biomimetic reactions with Fe(II). The CL has been induced by FeSO(4) and/or the FeCl(3)/L-cysteine/Rhodamine G system in aqueous (50%) acetonitrile. The light emission in the visible spectral region has been recorded for triterpenoid-based 1,2, 4-trioxolanes, purely synthetic ozonide OZ03, bicyclic 1,2,4, 5-tetroxanes, a tetroxane derived from deoxycholic acid, the diperoxide of trifluoroacetone, as well as the natural artemisinin. The herein discovered CL provides a promising perspective for the study of pharmacologically active peroxides in biomedical applications.

引用

页码：107 / 110

页数：4

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